51285-05-3

Basic information

• Product Name: N'-HYDROXY-2-PYRAZINECARBOXIMIDAMIDE
• Synonyms: PYRAZINE-2-CARBOXAMIDE OXIME;RARECHEM BG FB 0042;N'-HYDROXY-2-PYRAZINECARBOXIMIDAMIDE;BUTTPARK 32\04-58;Pyrazinecarboximidamide,N-hydroxy-;Pyrazinecarboximidamide, N-hydroxy- (9CI);N'-hydroxypyrazine-2-carboximidamide;Pyrazine-2-amidoxime
• CAS NO: 51285-05-3
• Molecular Formula: C₅H₆N₄O
• Molecular Weight: 138.13
• Product Categories: AMIDINE;OXIME
• Mol File: 51285-05-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 179-182°C
• Boiling Point: 370.3°Cat760mmHg
• Flash Point: 177.8°C
• Appearance: /
• Density: 1.49g/cm³
• CAS DataBase Reference: N'-HYDROXY-2-PYRAZINECARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N'-HYDROXY-2-PYRAZINECARBOXIMIDAMIDE(51285-05-3)
• EPA Substance Registry System: N'-HYDROXY-2-PYRAZINECARBOXIMIDAMIDE(51285-05-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-41-37/38-25
• Safety Statements: 26-36/37/39-45-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 51285-05-3(Hazardous Substances Data)

Usage

Description

Pyrazine-2-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis.

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 

Downstream Products

• 1401223-32-2 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide 
• 1401223-31-1 N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide 
• 1401223-74-2 (Z)-N'-(2-chloroacetoxy)pyrazine-2-carboximidamide 
• 114346-87-1 C₁₂H₁₀N₄O₂ 
• 114347-13-6 3-(pyrazin-2-yl)-4H-[1,2,4]oxadiazol-5-one 
• 345631-79-0 3-pyrazin-2-yl-4H-[1,2,4]oxadiazole-5-thione 
• 1347755-41-2 2-methoxy-4-[3-(pyrazin-2-yl)-[1,2,4]oxadiazol-5-yl]-phenol 
• 1347755-38-7 4-[5-(2,5-dimethoxyphenyl)-[1,2,4]oxadiazol-3-yl]-pyridine 

Relevant articles and documents

ATF6 MODULATORS AND USES THEREOF

Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

In Vitro Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action

The programmed cell death protein 1 (PD-1) signaling axis is among the most important therapeutic targets in modern oncology. Aurigene Discovery Technologies Ltd. (Aurigene) has patented a series of peptidomimetic small molecules derived from the PD-1 pro

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole and agonists of free fatty acid receptor 1. A library of 4 948 100 synthesizable drug-like 3,5-disubstituted 1,2,4-oxadiazoles was enumerated based on the method and available validated reagents.