51372-28-2 Usage
Description
(S)-16alpha,17-(butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione, also known as Budesonide 22S epimer, is a chemical compound derived from the pregnane family of steroids. It is an off-white solid with distinct chemical properties that make it useful in various applications, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(S)-16alpha,17-(butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione is used as an active pharmaceutical ingredient for the treatment of various inflammatory conditions. Its anti-inflammatory properties make it effective in managing asthma, allergic rhinitis, and other respiratory disorders. It is also used for the treatment of certain gastrointestinal conditions, such as Crohn's disease and ulcerative colitis.
Brand names:
(S)-16alpha,17-(butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione is marketed under various brand names, including Entocort (AstraZeneca), Pulmicort (AstraZeneca), and Rhinocort (AstraZeneca), which are used in different formulations and dosages to cater to the specific needs of patients with various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 51372-28-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,3,7 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51372-28:
(7*5)+(6*1)+(5*3)+(4*7)+(3*2)+(2*2)+(1*8)=102
102 % 10 = 2
So 51372-28-2 is a valid CAS Registry Number.
51372-28-2Relevant articles and documents
STEROIDS AND PROTEIN-CONJUGATES THEREOF
-
Paragraph 0625-0627, (2018/05/27)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS
-
, (2016/08/23)
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
Process for preparing budesonide
-
Page/Page column 6-7, (2009/10/21)
A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16α-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the reaction of step b) with water. The process of the invention enables the ratio between the A and B epimers of budesonide to be controlled.
