5138-73-8Relevant articles and documents
Synthesis and quantitative structure-activity relationships of O,O-diaryl O-methyl phosphorothionates for their antifungal activity against Sclerotium rolfsii
Gupta, R L,Roy, N K
, p. 334 - 337 (2007/10/02)
Twenty O,O diaryl O-methyl phosphorothionates have been synthesised and tested for their fungitoxicity in vitro against Sclerotium rolfsii.A few of these compounds exhibit very high fungitoxicity.O,O-Di(2,4,6-trichlorophenyl) O-methyl phosphorothionate is found to be the most active compound in this series and possess an excellent activity against S. rolfsii.The structure-activity relationships have been analysed by means of multiple regression analysis using physico-chemical substituent parameters for hydrophobic, electronic and steric properties.The fungicidalactivity of the compounds in this series is found to be correlated with the minimum width of the substituents of ortho- and meta-positions expressed in terms of STERIMOL parameter B1, i.e.B1(o) and B1(m) respectively and also with the lipophilicity of the substituents expressed by ?.Further, the activity of the compounds in this series against S. rolfsii increases with an increase in B1(o) and ? and a decrease in B1(m).
