514-21-6 Usage
Description
3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide 16-formate, also known as digoxin-16-formate, is a complex chemical compound with a steroid backbone. It features three hydroxyl groups at the 3rd, 14th, and 16th carbon positions of the steroid ring, and a formate group at the 16th position. 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide 16-formate is related to the cardiac glycoside family, which has been used for centuries in the treatment of heart conditions.
Uses
Used in Cardiology:
3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide 16-formate is used as a pharmacological agent in cardiology for its potential applications in treating heart conditions. It works by increasing the contractility of the heart muscle, similar to other cardiac glycosides. Further research into its properties and effects may lead to new developments in the treatment of heart disease.
Check Digit Verification of cas no
The CAS Registry Mumber 514-21-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 514-21:
(5*5)+(4*1)+(3*4)+(2*2)+(1*1)=46
46 % 10 = 6
So 514-21-6 is a valid CAS Registry Number.
514-21-6Relevant articles and documents
Cardiac Glycosides. 6. Gitoxigenin C16 Acetates, Formates, Methoxycarbonates, and Digitoxosides. Synthesis and Na+, K+ -ATPase Inhibitory Activities
Hashimoto, Toshihiro,Rathore, Hargovind,Satoh, Daisuke,Hong, George,Griffin, Jane F.,et al.
, p. 997 - 1003 (2007/10/02)
A series of 17 gitoxigenin 16β-formates, acetates, and methoxycarbonates was synthesized, including their 3β-acetates, formates, and digitoxosides.A 16β-formate group was generally found to increase activity 30 times, a 16β-acetate group 9-12 times, while a 16β-methoxycarbonate decreased activity by two-thirds. 3β-Formates and acetates had little effect on activity by themselves, but sometimes reduced the activity-increasing properties of 16β-formates and acetates.A 3β-digitoxoside increases the activity of ditoxigenin by 15 times, but the effect is less ifthe 16β-group is esterified.And finally, a 16-one decreases activity dramatically.These data suggest an important role for C16 esters and possibly the presence of a separate binding site on Na+, K+ -ATPase corresponding to the cardenolide C16 position.
