51431-61-9Relevant articles and documents
Regiodiverse three-component synthesis of arenes
Danz, Michael,Hilt, Gerhard
supporting information; experimental part, p. 303 - 308 (2011/04/18)
A ruthenium-catalyzed enyne metathesis reaction followed by a cobalt-catalyzed Diels-Alder reaction and oxidation of the dihydroaromatic intermediate generates the two regioisomeric aromatic products in good overall yields in a one-pot procedure. The regiochemistry of the cycloaddition can be controlled by the ligand choice on the cobalt catalyst to generate the product with the 1,3,5-or the 1,2,4-substitution pattern predominantly. The high functional group tolerance was used to generate bifunctionalized building blocks and finally an unprecedented regioselective Scholl reaction is described.