51436-99-8

Basic information

• Product Name: 4-Bromo-2-fluorotoluene
• Synonyms: 4-BROMO-2-FLUORO-1-METHYL-BENZENE;4-BROMO-2-FLUOROTOLUENE;2-FLUORO-4-BROMOTOLUENE;4-Bromo-2-fluorotoluene,98%;Bromofluorotoluene7;4-Bromo-Z-Fluorotoluene;4-Bromo-2-fluorotoluene,99%;4-Bromo-2-fluorotoluene 99%
• CAS NO: 51436-99-8
• Molecular Formula: C₇H₆BrF
• Molecular Weight: 189.02
• EINECS: 257-201-3
• Product Categories: Fluorin-contained toluene series;Fluorobenzene;Aromatic Halides (substituted);Halogen toluene;Miscellaneous;Bromine Compounds;Fluorine Compounds;Aryl;C7;Halogenated Hydrocarbons;Purines
• Mol File: 51436-99-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 68 °C (8 mmHg)
• Flash Point: 169 °F
• Appearance: colorless to light yellow liquid
• Density: 1.492 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.19mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: water: insoluble
• Water Solubility: INSOLUBLE
• BRN: 1859028
• CAS DataBase Reference: 4-Bromo-2-fluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-fluorotoluene(51436-99-8)
• EPA Substance Registry System: 4-Bromo-2-fluorotoluene(51436-99-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-52/53
• Safety Statements: 26-61-37/39
• RIDADR: UN 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 51436-99-8(Hazardous Substances Data)

Usage

Description

4-Bromo-2-fluorotoluene is an organic compound that features a toluene molecule with a bromine atom at the 4th position and a fluorine atom at the 2nd position. It is a colorless to light yellow liquid and serves as a versatile building block in the synthesis of various chemical compounds.

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-fluorotoluene is used as a starting reagent for the synthesis of 4-borono-2-fluorophenylalanine, which is a useful reagent for positron emission tomographic (PET) studies. This application is significant in the field of medical imaging, particularly in the detection and diagnosis of various diseases and conditions.
Used in Chemical Synthesis:
4-Bromo-2-fluorotoluene is also used in the synthesis of methyl 4-bromo-2-methoxybenzoate, a compound that may have potential applications in various chemical and pharmaceutical processes. Its unique structure allows for further functionalization and modification, making it a valuable intermediate in the development of new compounds with specific properties and applications.

InChI:InChI=1/C7H6BrF/c1-5-4-6(8)2-3-7(5)9/h2-4H,1H3

Upstream product

• 119-32-4 4-Methyl-3-nitroanilin 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 39478-78-9 5-bromo-2-methylaniline 

Downstream Products

• 170572-49-3 2-fluoro-4-cyanotoluene 
• 168267-99-0 (3-fluoro-4-methylphenyl)boronic acid 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 292050-23-8 2-[1-Acetylamino-2-(4-borono-2-fluorophenyl)ethyl]malonic acid diethyl ester 
• 168473-48-1 2-(5-amino-2-bromophenyl)-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one 
• 1028302-75-1 N-{4-Bromo-3-[3-ethyl-4-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-propionamide 
• 1027161-77-8 Pentanoic acid {4-bromo-3-[4-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-amide 
• 159547-39-4 5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one 
• 159547-32-7 2-(5-Amino-2-chlorophenyl)-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]-methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 159547-23-6 2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 168473-73-2 2-[2-chloro-5-(valerylamino)phenyl]-2,4-dihydro-5-ethyl-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one 
• 168473-50-5 2-[2-Bromo-5-(valerylamino)phenyl]-2,4-dihydro-5-ethyl-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one 
• 1027410-43-0 N-{4-Bromo-3-[4-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-5-oxo-3-propyl-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-propionamide 
• 168473-75-4 N-{4-Chloro-3-[3-ethyl-4-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-2-ethoxy-acetamide 

Relevant articles and documents

Syntheses of 4-methoxymethylbenzyl permethrinates containing fluorine and their insecticidal activity

In order to investigate the relationship between the position of fluorine atom and insecticidal activity about 4-methoxymethylbenzyl permethrinates containing fluorine, 2 and 3-fluoro-4-methoxymethylbenzyl (±)-cis-permethrinate were synthesized. Their insecticidal activities were tested and the fluorine effect of title compounds was discussed.