51449-77-5

Basic information

• Product Name: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE;2-(1H-Tetrazol-5-yl)phenol, 97%;5-(o-Hydroxyphenyl)tetrazole
• CAS NO: 51449-77-5
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.14874
• Mol File: 51449-77-5.mol
• Article Data: 74

Chemical Properties

• Melting Point: 230°C
• Boiling Point: 391.8 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.458 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)
• EPA Substance Registry System: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51449-77-5(Hazardous Substances Data)

Usage

General Description

5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is a chemical compound with the molecular formula C7H6N4O. It is a type of tetrazole derivative that contains a hydroxyphenyl group. 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is commonly utilized in organic chemistry and pharmaceutical research, particularly for its potential as a ligand in metal coordination chemistry and as a building block for drug design. It has also been studied for its potential biological activities, including anti-inflammatory and anti-cancer properties. Additionally, 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE may also have potential applications in material science and as a component in the synthesis of complex organic molecules.

InChI:InChI=1/C7H6N4O/c12-6-4-2-1-3-5(6)7-8-10-11-9-7/h1-4,12H,(H,8,9,10,11)

Upstream product

• 90-02-8 salicylaldehyde 
• 611-20-1 salicylonitrile 
• 68314-54-5 1-bromo-2-(methoxymethoxy)benzene 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 533-58-4 2-Iodophenol 
• 95-56-7 2-hydroxybromobenzene 
• 94-67-7 salicylaldehyde-oxime 
• 96-10-6 diethyl aluminiumcholoride 

Downstream Products

• 172352-72-6 tetrazolylphenyl pivalate 
• 473731-78-1 C₇H₅N₅O₃ 
• 76310-71-9 2-bromo-1-<4-hydroxy-3-(1H-tetrazol-5-yl)phenyl>ethanone 
• 611-20-1 salicylonitrile 
• 539-80-0 Tropone 
• 95-48-7 ortho-cresol 
• 76310-72-0 <(4-hydroxy-3-1H-tetrazol-5-yl)phenyl>ethanone 

Relevant articles and documents

Synthesis and characterization of magnetic Fe3O4@Creatinine@Zr nanoparticles as novel catalyst for the synthesis of 5-substituted 1H-tetrazoles in water and the selective oxidation of sulfides with classical and ultrasonic methods

Tetrazoles and sulfoxide compounds have a wide range of applications in industries and are of great expectation to be environmentally friendly and cost-effective. This paper reports the introduction of zirconium supported on Fe3O4 na

Catalytic conversion of 2,4,5-trisubstituted imidazole and 5-substituted 1H-tetrazole derivatives using a new series of half-sandwich (η6-p-cymene)Ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazone ligands

A new series of half-sandwich (η6-p-cymene) ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazide derivatives [Ru(η6-p-cymene)(Cl)(L)] [L = N'-(naphthalen-1-ylmethylene)thiophene-2-carbohydrazide (L1), N'-(anthracen-9-ylmethylene)thiophene-2-carbohydrazide (L2) and N'-(pyren-1-ylmethylene)thiophene-2-carbohydrazide (L3)] were synthesized. The ligand precursors and their Ru(II) complexes (1–3) were structurally characterized by spectral (IR, UV–Vis, NMR and mass spectrometry) and elemental analysis. The molecular structures of the ruthenium(II) complexes 1–3 were determined by single-crystal X-ray diffraction. All complexes were used as catalysts for the one-pot three-component syntheses of 2,4,5-trisubstitued imidazole and 5-substituted 1H-tetrazole derivatives. The catalytic studies optimized parameters as solvent, temperature and catalyst. The catalysts revealed very active for a broad range of aromatic aldehydes presenting either electron attractor or electron donor substituents and, although less active, moderate to high activities were observed for alkyl aldehydes.

The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route

Today, most synthetic methods are aimed at carrying out reactions under more efficient conditions and the realization of the twelve principles of green chemistry. Due to the importance and widespread applications of tetrazoles in various industries, especially in the field of pharmaceutical chemistry, and the expansion of the use of nanocatalysts in the preparation of valuable chemical reaction products, we decided to use an (Fe3O4@NFC@NSalophCu)CO2H nanocatalyst in this project. In this study, the synthesis of the nanocatalyst (Fe3O4@NFC@NSalophCu)CO2H was explained in a step-by-step manner. Confirmation of the structure was obtained based on FT-IR, EDX, FE-SEM, TEM, XRD, VSM, DLS, TGA, H-NMR, and CHNO analyses. The catalyst was applied to the synthesis of 5-substituted-1H-tetrazole and 1-substituted-1H-tetrazole derivatives through multi-component reactions (MCRs), and the performance was assessed. With advances in science and technology and increasing environmental pollution, the use of reagents and methods that are less dangerous for the environment has received much attention. Therefore, following green chemistry principles, with the help of the (Fe3O4@NFC@NSalophCu)CO2H salen complex as a nanocatalyst that is recyclable, cheap, safe, and available, the use of water as a green solvent, and reduced reaction times, the synthesis of tetrazoles can be achieved.