51481-60-8

Basic information

• Product Name: Naloxone hydrochloride dihydrate
• Synonyms: 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate;NALOXONE HYDROCHLORIDE, DIHYDRATE;naloxone F&D version of N7758;Naloxone HCl dihydrate;NALOXONE F&D VERSION OF N7758 FOR &;NALOXONE F&D VERSION OF N7758 FOR HUMA&;NaloxonHCl-Dihydrat;NaloxonhydrochloridDihydrat
• CAS NO: 51481-60-8
• Molecular Formula: C19H26ClNO6
• Molecular Weight: 399.87
• EINECS: 206-611-0
• Product Categories: Opioids;Antagonists;Pharmacologicals;Enzyme Inhibitors;Enzyme Inhibitors by Type;Other
• Mol File: 51481-60-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 182 °C (dec.)(lit.)
• Appearance: white to off-white/powder
• Storage Temp.: 2-8°C
• Solubility: ethanol: 3.3 mg/mL stable for several months refrigerated i
• Merck: 13,6388
• BRN: 6260807
• CAS DataBase Reference: Naloxone hydrochloride dihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Naloxone hydrochloride dihydrate(51481-60-8)
• EPA Substance Registry System: Naloxone hydrochloride dihydrate(51481-60-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-26-36/37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 51481-60-8(Hazardous Substances Data)

Usage

Description

Naloxone hydrochloride dihydrate is a specific opioid antagonist, also known as a narcotic antagonist. It is a white or almost white, hygroscopic, crystalline powder.

Uses

Used in Pharmaceutical Industry:
Naloxone hydrochloride dihydrate is used as an opioid antagonist for reversing the effects of opioid overdose. It works by binding to the opioid receptors in the brain, blocking the action of opioids and helping to restore normal respiration.
Used in Emergency Medicine:
Naloxone hydrochloride dihydrate is used as an emergency treatment for opioid overdose, particularly in cases where patients are experiencing respiratory depression or have stopped breathing. It is administered as an injection or through a nasal spray to rapidly counteract the life-threatening effects of opioids.
Used in Addiction Treatment:
Naloxone hydrochloride dihydrate is used as a component in addiction treatment programs, where it is combined with other medications to help reduce the risk of overdose and encourage patients to seek help for their addiction. It is also used in the form of an implant or depot injection to help manage opioid dependence.
Used in Preclinical Research:
Naloxone hydrochloride dihydrate is used as a research tool in preclinical studies to investigate the effects of opioids on various physiological processes and to develop new medications for the treatment of opioid addiction and overdose.

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

InChI:InChI=1/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1