51491-68-0

Basic information

• Product Name: 2-phenylacrylyl chloride
• Synonyms: 2-phenylacrylyl chloride
• CAS NO: 51491-68-0
• Molecular Weight: 166.607
• Mol File: 51491-68-0.mol
• Article Data: 65

Chemical Properties

• CAS DataBase Reference: 2-phenylacrylyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylacrylyl chloride(51491-68-0)
• EPA Substance Registry System: 2-phenylacrylyl chloride(51491-68-0)

Safety Data

• Hazardous Substances Data: 51491-68-0(Hazardous Substances Data)

Upstream product

• 149423-39-2 tropoyl chloride 
• 108-86-1 bromobenzene 
• 2613-89-0 phenylmalonic acid 
• 3967-53-1 methyl tropate 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 529-64-6 Tropic acid 
• 492-38-6 2-phenylacrylic acid 

Downstream Products

• 83126-69-6 2-Phenyl-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 1229699-55-1 3-(2-phenylacryloyl)oxazolidin-2-one 
• 1403475-41-1 C₁₆H₁₃Br₂NO 
• 60782-00-5 9-methyl-2-phenyl-3H-pyrrolo[1,2-a]indol-3-one 
• 1361029-72-2 (Z)-methyl 3-(3-methyl-1H-indol-2-yl)-2-phenylacrylate 
• 1361029-53-9 1-(3-methyl-1H-indol-1-yl)-2-phenylprop-2-en-1-one 
• 1353569-38-6 1-methyl-3-phenyl-3-(2,2,2-trifluoroethyl)indoline-2-one 
• 1277185-91-7 N-benzyl-N-isopropenyl-2-phenylacrylamide 
• 827026-74-4 (S)-5,5-dimethyl-4-iso-propyl-3-(2'-phenylacryloyl)oxazolidin-2-one 

Relevant articles and documents

RhIII-Catalyzed C-H (Het)arylation/Vinylation of N-2,6-Difluoroaryl Acrylamides

RhIII-catalyzed sp2 C-H cross-coupling of acrylamides with organoboron reactants has been accomplished using a commercially available N-2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability can serve as the coupling partners. This transformation proceeds under moderate reaction conditions with excellent functional group tolerance and high regioselectivity.

Photoredox Cyclization of N-Arylacrylamides for Synthesis of Dihydroquinolinones

Metal- and additive-free photoredox cyclization of N-arylacrylamides is herein reported that provides a concise access to the formation of dihydroquinolinones. In this protocol, sustainable visible light was used as the energy source, and the organic light-emitting molecule 4CzIPN served as the efficient photocatalyst. This reaction system features exclusive 6-endo-trig cyclization selectivity with a generally good yield of a range of functionalized dihydroquinolinones and dihydrobenzoquinolinones. Mechanistical studies reveal the feasibility of both 1,3-H shift and intersystem crossing of the diradical intermediate.

THERAPEUTIC COMPOUNDS AND METHODS OF USE

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.