51509-99-0

Basic information

• Product Name: 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-phenyl-
• CAS NO: 51509-99-0
• Molecular Formula: C15H18O4
• Molecular Weight: 262.306
• Mol File: 51509-99-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-phenyl-(51509-99-0)
• EPA Substance Registry System: 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-phenyl-(51509-99-0)

Safety Data

• Hazardous Substances Data: 51509-99-0(Hazardous Substances Data)

Upstream product

• 3592-25-4 1,5-dichloropentan-3-one 
• 25288-77-1 8-(4-chloro-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 140-29-4 phenylacetonitrile 
• 51509-98-9 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril 
• 75945-89-0 2.2-Bis-β-chlorethyl-1.3-dioxolan 

Downstream Products

• 51510-02-2 4-acetoxymethyl-4-phenylcyclohexanone 
• 51510-01-1 4-(hydroxymethyl)-4-phenylcyclohexanone 
• 1189796-24-4 8-phenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid-butyl-methylamide 
• 1189796-19-7 8-phenyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid-benzyl-methylamide 
• 79741-33-6 methyl-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)amine 
• 77253-85-1 dimethyl-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)amine 
• 75945-93-6 (cis-4-Methylamino-1-phenyl)-cyclohexancarbonsaeuremethylester 
• 75945-92-5 4-Methylamino-1-phenyl-cyclohexancarbonsaeuremethylester 
• 75945-94-7 4-Benzylamino-1-phenyl-cyclohexancarbonsaeuremethylester 
• 75945-95-8 2-Benzyl-4-phenyl-2-azabicyclo<2.2.2>octan-3-on 
• 75945-96-9 2-Benzyl-4-phenyl-2-azabicyclo<2.2.2>octan 
• 75945-90-3 4-Oxo-1-phenyl-cyclohexancarbonsaeuremethylester 
• 63383-64-2 2-Methyl-4-phenyl-2-azabicyclo<2.2.2>octan-3-on 
• 63383-74-4 2-Methyl-4-phenyl-2-azabicyclo<2.2.2>octan 

Relevant articles and documents

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.

SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES

The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.

Synthesis and Reactivity of 4-Phenylisoquinuclidines

Several approaches to the synthesis of the 2-alkyl-4-phenylisoquinuclidines 14 and 15, the 3,4-diphenylisoquinuclidines 22-24 and of 6-oxo-4-phenyl-3-isoquinuclidone (43) are described.The structure of the products of hydrolysis of 7-phenyl-1,4-dioxaspirodecanecarboxamide (36) were determined by spectroscopy and degradative reactions.