51522-07-7

Basic information

• Product Name: 4-chloro-3-methylsulfonyl-benzoic acid
• Synonyms: 3-Methylsulphonyl-4-chlorobenzoic acid
• CAS NO: 51522-07-7
• Molecular Formula: C₈H₇ClO₄S
• Molecular Weight: 234.66
• Mol File: 51522-07-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 485.2°Cat760mmHg
• Flash Point: 247.3°C
• Appearance: /
• Density: 1.507g/cm³
• Vapor Pressure: 3.15E-10mmHg at 25°C
• PKA: 3.37±0.10(Predicted)
• CAS DataBase Reference: 4-chloro-3-methylsulfonyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-methylsulfonyl-benzoic acid(51522-07-7)
• EPA Substance Registry System: 4-chloro-3-methylsulfonyl-benzoic acid(51522-07-7)

Safety Data

• Hazardous Substances Data: 51522-07-7(Hazardous Substances Data)

Usage

Description

4-chloro-3-methylsulfonyl-benzoic acid is a chemical compound with the molecular formula C8H7ClO4S. It is a white crystalline solid that is soluble in organic solvents.
Used in Pharmaceutical Industry:
4-chloro-3-methylsulfonyl-benzoic acid is used as an intermediate in the synthesis of pharmaceuticals for its anti-inflammatory properties, which may be utilized in the development of new drugs for treating various inflammatory conditions.
Used in Agrochemical Industry:
4-chloro-3-methylsulfonyl-benzoic acid is used as an intermediate in the synthesis of agrochemicals, contributing to the development of products for agricultural applications.
Used in Materials Science:
4-chloro-3-methylsulfonyl-benzoic acid has potential applications in the field of materials science, serving as a building block for the synthesis of functional materials due to its unique chemical properties.
Its chemical properties make 4-chloro-3-methylsulfonyl-benzoic acid an important compound with potential applications in various fields.

InChI:InChI=1/C8H7ClO4S/c1-14(12,13)7-4-5(8(10)11)2-3-6(7)9/h2-4H,1H3,(H,10,11)/p-1

Upstream product

• 2494-79-3 4-chloro-3-(chlorosulfonyl)benzoic acid 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 74-11-3 para-chlorobenzoic acid 
• 200423-20-7 4-Chloro-3-hydroxysulfinylbenzoic acid 
• 74-88-4 methyl iodide 
• 157069-50-6 4-chloro-3-(methylsulfonyl)benzoic acid methyl ester 

Downstream Products

• 190367-99-8 4-(3-Hydroxy-piperidin-1-yl)-3-methanesulfonyl-benzoic acid 
• 135051-09-1 3-methylsulfonyl-4-(1-piperidino)benzoic acid 
• 1186514-83-9 N-(1-(4-chloro-3-(methylsulfonyl)phenyl)ethyl)-4'-methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxamide 
• 1186518-70-6 4-(1-azodoethyl)-1-chloro-2-(methylsulfonyl)benzene 
• 1186519-64-1 1-(4-chloro-3-(methylsulfonyl)phenyl)ethanol 
• 1186519-63-0 1-(4-chloro-3-(methylsulfonyl)phenyl)ethanone 
• 1073429-16-9 1-(4-chloro-3-(methylsulfonyl)phenyl)ethanamine 
• 1431501-02-8 (3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxyphenyl)(4-morpholinyl)methanone 
• 1431501-01-7 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzamide 
• 32548-16-6 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid 
• 1431501-31-3 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid sodium salt 
• 1431505-03-1 ethyl 4-chloro-3-(methylsulfonyl)-5-nitrobenzoate 
• 1431505-02-0 methyl 3-(methylsulfonyl)-4-phenoxy-5-(2,2,2-trifluoroethylamino)benzoate 
• 1431505-01-9 methyl 3-(methylsulfonyl)-4-phenoxy-5-(piperidin-1-yl)benzoate 

Relevant articles and documents

2,3,5 TRISUBSTITUTED ARYL AND HETEROARYL AMINO DERIVATIVES, COMPOSITIONS, AND METHODS OF USE

Compounds are disclosed that have a formula represented by the following:(I) wherein Cy, L1 R1, R2a, R2b, R3, R4, n, and L2 are as described herein. These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, itch, excessive itch, Pruritis, neuropathic pruritis, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors

We have identified a new class of chymase inhibitor through a substituent analysis of MWP00965, which we previously discovered by in silico screening. TY-51076 (7) showed high potency (IC50=56 nM) and excellent selectivity for chymase compared to chymotrypsin and cathepsin G (>400-fold). The synthesis and structure-activity relationship of this class are described.

Benzoylguanidines, a process for their preparation, their use as medicaments and medicaments containing them

Benzoylguanidines of the formula I STR1 where R(1) or R(2) is equal to R(6)--S(O)n -- or R(7)R(8)N--O2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O)n or R(7)R(8)N-- and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(7) and R(8) are equal to alkyl or phenylakyl or phenyl, and in which R(7) and R(8) may also together be a C4 -C7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(5) are together an alkylene chain, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.