51524-71-1 Usage
Description
C2-HSL, N-Acetyl-L-hoMoserine lactone, belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. It is the shortest alkyl homologue and most polar of a family of mediators of cell-cell interactions in bacterial biofilms. Unlike other HSLs, C2-HSL does not elicit a response in bacteria and serves as a polar negative control for quorum sensing events.
Uses
Used in Research Applications:
C2-HSL, N-Acetyl-L-hoMoserine lactone, is used as a research tool for studying bacterial communication and quorum sensing mechanisms. Its inability to induce a response in bacteria makes it a valuable control in experiments involving the investigation of quorum sensing and its role in bacterial biofilm formation and regulation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, C2-HSL, N-Acetyl-L-hoMoserine lactone, is used as a potential therapeutic agent for targeting bacterial biofilms. Its unique properties allow researchers to explore its potential in disrupting quorum sensing pathways, which could lead to the development of new antibiotics or anti-biofilm treatments.
Used in Environmental Applications:
C2-HSL, N-Acetyl-L-hoMoserine lactone, can be used in environmental applications to control and manage bacterial biofilms, particularly in water treatment and industrial systems where biofouling can cause significant problems. By understanding the role of quorum sensing in biofilm formation, C2-HSL can be utilized to develop strategies to prevent or reduce biofilm-related issues.
Check Digit Verification of cas no
The CAS Registry Mumber 51524-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,2 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 51524-71:
(7*5)+(6*1)+(5*5)+(4*2)+(3*4)+(2*7)+(1*1)=101
101 % 10 = 1
So 51524-71-1 is a valid CAS Registry Number.
51524-71-1Relevant articles and documents
1,5-Asymmetric induction in reactions between 4- and 5-alkoxypent-2-enyl(tributyl)stannanes and achiral 1-alkoxycarbonylimines
Hallet,Thomas
, p. 2575 - 2578 (1995)
Tin(IV) chloride promoted reactions of 4- and 5-alkoxypent-2-enyl(tributyl)stannanes 1, 11 and 15 and 1-alkoxycarbonylimines 2 proceed with excellent 1,5-asymmetric induction.
Solution structural features of N-acyl homoserine lactones
Tumminakatti, Shama,Khatri, Bhavesh,Krishnamurti, Vinayak,Athavale, Vishikh,Prabhakaran, Erode N.
supporting information, p. 5771 - 5775 (2015/09/29)
Here we demonstrate that in interbacterial quorum signal moderators, N-acylhomoserine lactones (AHLs), the stabilization of bioactive pharmacophore lactone against lysis is through the e- withdrawing N-acyl motif which reduces lactone carbonyl polarization. This lysis is assisted by weak (-1) contacts between N-acyl O and lactone C′. The interactions that preclude this weak contact, in the free and receptor-bound AHLs, improve lactone halflife and hence are key to the design of the antibacterial AHL analogues.
Exciton chirality method in vibrational circular dichroism
Taniguchi, Tohru,Monde, Kenji
supporting information; experimental part, p. 3695 - 3698 (2012/04/11)
The interaction of two IR chromophores yields a strong vibrational circular dichroism couplet whose sign reflects the absolute configuration of the molecule. We present a method to determine absolute configuration of a chiral molecule based on this couplet without need of theoretical calculation. Not only can this method analyze various molecules whose absolute configuration is difficult to determine by other spectroscopic methods, but also it can significantly enhance VCD signals.
