5153-70-8

Basic information

• Product Name: 4'-CHLORO-BETA-NITROSTYRENE
• Synonyms: Styrene, p-chloro-.beta.-nitro-, (E)- (8CI);Benzene, 1-chloro-4-(2-nitroethenyl)-, (E)-;Styrene,p-chloro-.beta.-nitro-,(E)-;trans-p-Chloro-beta-nitrostyrene;trans-p-Chloronitrostyrene
• CAS NO: 5153-70-8
• Molecular Formula: C8H6ClNO2
• Molecular Weight: 183.593
• Mol File: 5153-70-8.mol
• Article Data: 202

Chemical Properties

• Melting Point: 115℃ (ligroine )
• Boiling Point: 299 °C at 760 mmHg
• Flash Point: 134.6 °C
• Appearance: /
• Density: 1.324 g/cm³
• CAS DataBase Reference: 4'-CHLORO-BETA-NITROSTYRENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLORO-BETA-NITROSTYRENE(5153-70-8)
• EPA Substance Registry System: 4'-CHLORO-BETA-NITROSTYRENE(5153-70-8)

Safety Data

• Statements: 22-43
• Safety Statements: 36/37
• Hazardous Substances Data: 5153-70-8(Hazardous Substances Data)

Usage

General Description

4'-Chloro-beta-nitrostyrene is a chemical compound with the molecular formula C9H7ClNO2. It is a yellow crystalline powder that is insoluble in water but soluble in organic solvents. 4'-CHLORO-BETA-NITROSTYRENE is primarily used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is also utilized in research and development of new chemical processes. 4'-Chloro-beta-nitrostyrene is known for its nitro group, which is a strong electron-withdrawing group, and its styrene structure, which gives it potential for polymerization and other chemical reactions. It is important to handle this compound with caution, as it may be hazardous if not properly managed.

Upstream product

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Downstream Products

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• 125742-29-2 ethyl 2-(4-chlorophenyl)-3-nitropropyl(diethoxymethyl)phosphinate 
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• 63509-22-8 [1-(4-Chloro-phenyl)-2-nitro-ethyl]-phosphonic acid dimethyl ester 
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• 4099-60-9 1-Chlor-2-<4-chlor-phenyl>-2-<4-fluor-phenyl>-1-oximino-aethan 

Relevant articles and documents

Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from l-proline and isatin, with various β-nitrostyrenes. Nitro-Sox compounds, 4b, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, respectively. Further studies with MTT assay, Raman spectroscopy, TEM and molecular docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer's disease pathology.

A green metal-free "one-pot" microwave assisted synthesis of 1,4-dihydrochromene triazoles

The synthesis of several 4-aryl-1,4-dihydrochromene-triazoles was achieved via a metal-free "one-pot"procedure using PEG400 as the sole solvent in an eco-friendly process. Using microwave irradiation, the triazole derivatives were obtained in good yields and short reaction times starting from readily accessible building blocks.

Skeletally Tunable Seven-Membered-Ring Fused Pyrroles

We describe a copper-mediated method that enables the synthesis of seven-membered-ring fused pyrroles (7-mrFPs). The protocol proceeds via an in situ spiro-intermediate ring expansion and tolerates a library of 7-mrFP derivatives with a broad range of functional groups in a simple step with tangible parameters and substrate adaptations. These rare 7-mrFPs are now accessible on a millimolar scale, and selected examples exhibit high antioxidant activity.