51549-36-1

Basic information

• Product Name: N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE
• Synonyms: N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE;N-Benzoyl-5'-O-tert-butyldiMethylsilyl-2'-deoxycytidine, 98+%
• CAS NO: 51549-36-1
• Molecular Formula: C₂₂H₃₁N₃O₅Si
• Molecular Weight: 445.58
• Mol File: 51549-36-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE(51549-36-1)
• EPA Substance Registry System: N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE(51549-36-1)

Safety Data

• Hazardous Substances Data: 51549-36-1(Hazardous Substances Data)

Usage

Description

N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE is a chemical compound derived from cytidine, a nucleoside found in RNA and DNA. It is modified with benzoyl and tert-butyldimethylsilyl groups at the 5' and 2' positions, respectively, which may improve its stability and pharmacokinetic properties. This modified nucleoside holds promise for use in pharmaceuticals and biotechnology, particularly in the development of nucleoside analogues for treating viral infections and cancer, as well as in biological and biochemical research.

Uses

Used in Pharmaceutical Industry:
N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE is used as a nucleoside analogue for the development of antiviral and anticancer drugs. Its unique structure and chemical properties allow it to potentially target and inhibit the replication of viruses and cancer cells, offering new therapeutic options for patients.
Used in Biotechnology Industry:
N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE is used as a research probe in biological and biochemical studies. Its modified structure allows for the investigation of nucleic acid interactions, enzymatic activities, and other biological processes, contributing to a better understanding of molecular mechanisms and the development of novel therapeutic strategies.

Upstream product

• 98-88-4 benzoyl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 951-77-9 2'-Deoxycytidine 
• 65-85-0 benzoic acid 
• 1548-84-1 pentafluorophenyl benzoate 
• 3019-98-5 pentachlorophenyl benzoate 

Downstream Products

• 1360780-15-9 N₄-benzoyl-5'-O-tert-butyldimethylsilyl-3'-O-[(N,N-diisopropylamino)methoxyphosphino]-2'-deoxycytidine 
• 1360780-19-3 C₄₅H₅₇N₈O₁₄PSi 
• 1360780-20-6 C₃₇H₅₁N₈O₁₂PSi 
• 1360780-24-0 C₄₄H₆₇N₉O₁₃P₂Si 
• 140712-80-7 N⁴-benzoyl-3'-O-dimethoxytrityl-2'-deoxycytidine 
• 329326-35-4 benzyl N-(2-((4-N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxycytidin-3'-O-yl)phosphonyl)ethyl)-N-(thymin-1-ylacetyl)glycinate 
• 869563-54-2 N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 116872-52-7 Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage

This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.

Synthesis of 3'-azido-3'-deoxythymidine-terminated oligonucleotide

A method of completely chemical synthesis of 3'-azido-3'- deoxythymidine-terminated oligonucleotides via 5'-H-phosphonate of AZT is described.

Synthesis and P-diastereomeric resolution of nucleoside 3'-O(S-alkyl) and nucleoside 3'-O(S-aryl) methylphosphonothioates

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