51564-92-2

Basic information

• Product Name: 2-Amino-6-chloro-4-picoline
• Synonyms: 2-Amino-6-chloro-4-picoline;6-Chloro-4-methylpyridin-2-amine;2-AMino-6-chloro-4-Methylpyridine;6-chloro-4-Methyl-2-PyridinaMine
• CAS NO: 51564-92-2
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.58618
• Product Categories: Pyridine;Aromatics;Bases & Related Reagents;Nucleotides
• Mol File: 51564-92-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 280.2 °C at 760 mmHg
• Flash Point: 123.2 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.00385mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.42±0.35(Predicted)
• CAS DataBase Reference: 2-Amino-6-chloro-4-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-chloro-4-picoline(51564-92-2)
• EPA Substance Registry System: 2-Amino-6-chloro-4-picoline(51564-92-2)

Safety Data

• Hazardous Substances Data: 51564-92-2(Hazardous Substances Data)

Usage

General Description

2-Amino-6-chloro-4-picoline is a chemical compound with the molecular formula C6H6ClN2. It is a member of the picoline family of chemicals, which are composed of a pyridine ring with a methyl and amino group attached at various positions. 2-Amino-6-chloro-4-picoline has a chlorine atom at the 6th position of the pyridine ring and an amino group at the 2nd position. It is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. The compound is considered to have low acute toxicity, but its specific effects on human health and the environment have not been extensively studied. However, it is important to handle this chemical with caution and use appropriate safety measures in its handling and storage.

InChI:InChI=1/C6H7ClN2/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3,(H2,8,9)

Upstream product

• 1004294-60-3 N-(6-chloro-4-methylpyridin-2-yl)pivalamide 
• 86847-77-0 2,2-Dimethyl-N-(4-methyl-2-pyridinyl)propanamide 
• 1004294-59-0 4-methylpyridin-2-ylpivalamide-1-oxide 
• 695-34-1 2-Amino-4-methylpyridine 
• 39621-00-6 2,6-dichloro-4-picoline 

Downstream Products

• 1083168-77-7 N-(6-chloro-4-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 
• 1083168-81-3 N-(6-chloro-4-methylpyridin-2-yl)-1-(2,3-dihydrobenzofuran-5-yl)cyclopropanecarboxamide 
• 1083168-08-4 1-(2,3-dihydrobenzofuran-5-yl)-N-(2'-methoxy-4-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-12-0 1-(2,3-dihydrobenzofuran-5-yl)-N-(2'-methoxy-4-methyl-2,4'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-10-8 1-(2,3-dihydrobenzofuran-5-yl)-N-(6'-methoxy-4-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-09-5 1-(2,3-dihydrobenzofuran-5-yl)-N-(4-methyl-6-(2-oxo-1,2-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-13-1 1-(2,3-dihydrobenzofuran-5-yl)-N-(4-methyl-6-(2-oxo-1,2-dihydropyridin-4-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-11-9 1-(2,3-dihydrobenzofuran-5-yl)-N-(4-methyl-6-(6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083167-69-4 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2'-methoxy-4-methyl-2,4'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-83-2 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6'-methoxy-4,4'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-80-9 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6'-methoxy-2',4-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-97-8 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2'-methoxy-4,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-86-5 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(4-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083167-98-9 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2'-hydroxy-4,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PAIN

The invention relates to compounds, pyridine derivatives, and pharmaceutical 10 compositions containing same for use in the treatment of pain. It also relates to specific compounds, compositions comprising the same and uses thereof, in particular in the treatment of pain.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.