51581-52-3

Basic information

• Product Name: 1-(3-CHLOROPHENYL)IMIDAZOLE
• Synonyms: 1-(3-Chlorophenyl)-1H-imidazole;1-(m-chlorophenyl)-imidazol;1-(m-Chlorophenyl)imidazole;1H-Imidazole, 1-(3-chlorophenyl)-;1-(3-CHLOROPHENYL)IMIDAZOLE;1-(m-Chlorophenyl)-1H-imidazole
• CAS NO: 51581-52-3
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Mol File: 51581-52-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 145°C 1mm
• Flash Point: 146.6 °C
• Appearance: /
• Density: 1,27 g/cm3
• Vapor Pressure: 0.000656mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 1-(3-CHLOROPHENYL)IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLOROPHENYL)IMIDAZOLE(51581-52-3)
• EPA Substance Registry System: 1-(3-CHLOROPHENYL)IMIDAZOLE(51581-52-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 51581-52-3(Hazardous Substances Data)

Usage

General Description

1-(3-chlorophenyl)imidazole is a chemical compound with the molecular formula C9H7ClN2. It is a white solid that is used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. 1-(3-CHLOROPHENYL)IMIDAZOLE contains an imidazole ring with a 3-chlorophenyl group attached to it, and it exhibits various biological activities such as anti-inflammatory, anti-fungal, and anti-bacterial properties. It is also used in the synthesis of fungicides and pesticides, as well as in research and development of new drugs. The compound is considered to be of moderate toxicity and should be handled with proper safety precautions in a laboratory setting.

InChI:InChI=1/C9H7ClN2/c10-8-2-1-3-9(6-8)12-5-4-11-7-12/h1-7H

Upstream product

• 288-32-4 1H-imidazole 
• 108-37-2 1-bromo-3-chlorobenzene 
• 625-99-0 3-iodochlorobenzene 

Downstream Products

• 51581-62-5 1-(3-chlorophenyl)-1H-imidazole-2-carbaldehyde 
• 143426-68-0 (3-imidazol-1-yl-phenyl)acetic acid ethyl ester 

Relevant articles and documents

Optimization of diarylpentadienones as chemotherapeutics for prostate cancer

Our earlier studies indicate that (1E,4E)-1,5-bis(1-alkyl-1H-imidazol-2-yl)penta-1,4-diene-3-ones and (1E,4E)-1,5-bis(1-alkyl-1H-benzo[d]imidazol-2-yl)penta-1,4-diene-3-ones exhibit up to 121-fold greater antiproliferative potency than curcumin in human p

A N - aryl pyrazole compounds and N - aryl imidazole compound of preparation method

The invention discloses a preparation method of an N-arylpyrazole compound and an N-arylimidazole compound. The method comprises the following steps: reacting at 20-120 DEG C for 6-48 hours by taking aryl halide and pyrazole or imidazole as substrates and copper salt as a catalyst in an organic solvent in the presence of alkali and a nitrogenous ligand under nitrogen protection; and after the reaction is finished, separating and purifying a reaction liquid to obtain the N-arylpyrazole compound or the N-arylimidazole compound. A product prepared by utilizing the method disclosed by the invention can not only be directly used, but also be used for other reactions as a substrate and has the advantages of moderation in adopted reaction condition, simple operation step and post-processing process, high yield and suitability for large-scale production.

Structure activity relationships in reactivators of organophosphorus inhibited acetylcholinesterase. VII. 1 Aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides

A series of 1 aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides, where the aryl group is either phenyl or substituted phenyl, was prepared and tested for their reactivating potency on phosphorylated acetylcholinesterase (AChE) and for anti AChE activity. The in vitro testing revealed that some of the new compounds are good reactivators. Correlations between their structure and biological activities have been attempted.