515846-46-5

Basic information

• Product Name: (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester
• Synonyms: (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester
• CAS NO: 515846-46-5
• Molecular Weight: 770.753
• Mol File: 515846-46-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester(515846-46-5)
• EPA Substance Registry System: (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester(515846-46-5)

Safety Data

• Hazardous Substances Data: 515846-46-5(Hazardous Substances Data)

Upstream product

• 738577-08-7 4-ethynylpiperidine 
• 550378-30-8 4-ethynylpiperidine hydrochloride salt 
• 515846-35-2 (R)-[1-(2-{4-[5-(2,3-dichloro-4-triisopropylsilanyloxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 515846-33-0 (R)-[1-(2-{4-[3-(2,3-dichloro-4-triisopropylsilanyloxy-phenyl)-3-oxo-prop-1-ynyl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 515846-24-9 (R)-{1-[2-(4-ethynyl-piperidin-1-yl)-2-oxo-ethylcarbamoyl]-3-methyl-butyl}carbamic acid tert-butyl ester 
• 550378-32-0 2-amino-1-(4-ethynyl-piperidin-1-yl)-ethanone; hydrochloride 
• 515846-30-7 2,3-dichloro-4-triisopropylsilanyloxy-benzoic acid 
• 515846-31-8 2,3-dichloro-4-triisopropylsilanyloxy-benzoyl chloride 
• 550378-31-9 [2-(4-ethynyl-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 515846-27-2 (4-bromo-2,3-dichloro-phenoxy)-triisopropyl-silane 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1940-44-9 4-bromo-2,3-dichlorophenol 
• 31719-77-4 3-chloromethylbenzoic acid 
• 16937-99-8 N-Boc-D-Leu 

Downstream Products

• 515846-48-7 (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid 

Relevant articles and documents

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)