516-58-5 Usage
Description
Allopregnan-20beta-ol-3-one, also known as 5α-Pregnan-20β-ol-3-one, is a 3-oxo steroid derived from the steroid hormone progesterone. It carries an additional hydroxy substituent at the 20beta-position and is involved in various biological processes, including the maturation and secretory activity of the uterine endothelium and suppression of ovulation. Progesterone, its precursor, has been implicated in the etiology of breast cancer.
Uses
Used in Pharmaceutical Industry:
Allopregnan-20beta-ol-3-one is used as a pharmaceutical compound for its potential role in modulating the maturation and secretory activity of the uterine endothelium. It is also being investigated for its suppressive effects on ovulation and its implications in the etiology of breast cancer.
Used in Research and Development:
In the field of research and development, allopregnan-20beta-ol-3-one serves as a valuable compound for studying the effects of steroid hormones on various biological processes, including reproductive health and cancer development. Its unique structure and properties make it a promising candidate for further investigation and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 516-58-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 516-58:
(5*5)+(4*1)+(3*6)+(2*5)+(1*8)=65
65 % 10 = 5
So 516-58-5 is a valid CAS Registry Number.
516-58-5Relevant articles and documents
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Marker et al.
, p. 614 (1937)
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Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase
Endo, Satoshi,Arai, Yuki,Hara, Akira,Kitade, Yukio,Bunai, Yasuo,El-Kabbani, Ossama,Matsunaga, Toshiyuki
, p. 1514 - 1518 (2013/10/08)
In this study, we examined the substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase (AKR1C5), which plays a role in the termination of pregnancy by progesterone inactivation. AKR1C5 moderately reduced the 3-keto group of only 5α-dihydrosteroids with 17β- or 20α/β-hydroxy group among 3-ketosteroids. In contrast, the enzyme reversibly and efficiently catalyzed the reduction of various 17- and 20-ketosteroids, including estrogen precursors (dehydroepiandrosterone, estrone and 5α-androstan-3β- ol-17-one) and tocolytic 5β-pregnane-3,20- dione. In addition to the progesterone inactivation, the formation of estrogens and metabolism of the tocolytic steroid by AKR1C5 may be related to its role in rabbit parturition. AKR1C5 also reduced various non-steroidal carbonyl compounds, including isatin, an antagonist of the C-type natriuretic peptide receptor, and 4-oxo-2-nonenal, suggesting its roles in controlling the bioactive isatin and detoxification of cytotoxic aldehydes. AKR1C5 was potently and competitively inhibited by flavonoids such as kaempferol and quercetin, suggesting that its activity is affected by ingested flavonoids.