51638-15-4

Basic information

• Product Name: Phosphonic acid, [2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]-, dimethyl ester
• CAS NO: 51638-15-4
• Molecular Formula: C11H12F3O4P
• Molecular Weight: 296.183
• Mol File: 51638-15-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]-, dimethyl ester(51638-15-4)
• EPA Substance Registry System: Phosphonic acid, [2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]-, dimethyl ester(51638-15-4)

Safety Data

• Hazardous Substances Data: 51638-15-4(Hazardous Substances Data)

Upstream product

• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 756-79-6 dimethyl methane phosphonate 

Downstream Products

• 75380-98-2 C₁₂H₁₁F₃O₃ 
• 1415922-52-9 dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate 
• 1415922-84-7 dimethyl (1-acetamido-2-oxo-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate 
• 1399822-32-2 dimethyl [2-hydroxy-2-(4-trifluoromethylphenyl)ethyl]phosphonate 
• 951231-33-7 (E)-3-cyclopropyl-1-(4-trifluoromethyl-phenyl)-propenone 

Relevant articles and documents

Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids

The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodology was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen.

Diastereo- and enantioselective asymmetric hydrogenation of α-amido-β-keto phosphonates via dynamic kinetic resolution

Dynamic kinetic resolution of various α-amido-β-keto phosphonates via asymmetric hydrogenation proceeded efficiently to give the corresponding β-hydroxy-α-amido phosphonates in high diastereo- and enantioselectivities (up to 99:1 syn/anti, 99.8% ee). The addition of catalytic amounts of CeCl3 3 7H2O is necessary to achieve both good selectivity and catalytic efficiency under mild reaction conditions.

PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGIUR2 ANTAGONISTS

The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders:wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.