51642-03-6Relevant articles and documents
INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
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Page/Page column 56, (2018/06/06)
The present invention relates to a compound represented by formula I': and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ( DGAT2 ) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
KINASE INHIBITOR COMPOUNDS
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Page/Page column 42, (2008/06/13)
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
HYDROLYSIS OF CARBAMATES AND CARBONATES OF 3-HYDROXYTHIOLANE 1,1-DIOXIDE
Parkhomenko, P. I.,Rybakova, M. V.,Bezmenova, T. E.,Zaika, T. D.
, p. 1122 - 1124 (2007/10/02)
Alkylcarbamates of 3-hydroxy-thiolane 1,1-dioxide are hydrolyzed in the presence of bases to give alkyl(1,1-dioxo-3-thiolanyl)amines and 2-thiolene 1,1-dioxide (I).Aryl esters undergo hydrolysis to give sulfone I and 3-hydroxythiolane 1,1-dioxide (II).The corresponding alkyl- and arylcarbonates also form sulfone I and a very small amount of hydroxy derivative II under these conditions.