51660-08-3

Basic information

• Product Name: 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE
• Synonyms: 4-CHLORO-3-PHENYLPYRIDAZIN-6-OL;5-CHLORO-6-PHENYLPYRIDAZIN-3-OL;5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE;5-CHLORO-2-METHYL-6-PHENYLPYRIDAZIN-3(2H)-ONE;AURORA KA-3948;4-Chloro-3-phenylpyridazin-6-ol, 5-Chloro-6-phenylpyridazin-3-ol;4-Chloro-6-hydroxy-3-phenylpyridazine 97%
• CAS NO: 51660-08-3
• Molecular Formula: C₁₀H₇ClN₂O
• Molecular Weight: 206.63
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 51660-08-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 235 °C
• Boiling Point: 403.2°Cat760mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 4.44E-07mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9?+-.0.60(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE(51660-08-3)
• EPA Substance Registry System: 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE(51660-08-3)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 51660-08-3(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE is a chemical compound that belongs to the dihydropyridazine class. It is a heterocyclic organic compound that contains a five-membered ring with two nitrogen atoms and three carbon atoms. 5-CHLORO-2-METHYL-6-PHENYL-2,3-DIHYDROPYRIDAZIN-3-ONE is characterized by the presence of a chloro group, a methyl group, and a phenyl group on its structure. It has potential applications in the pharmaceutical and chemical industries, and its structure and properties make it a subject of interest for research and development.

InChI:InChI=1/C10H7ClN2O/c11-8-6-9(14)12-13-10(8)7-4-2-1-3-5-7/h1-6H,(H,12,14)

Upstream product

• 71-43-2 benzene 

Downstream Products

• 132814-12-1 6-phenyl-5-(N⁴-benzoyl-N¹-piperazinyl)-2H-pyridazin-3-one 
• 132814-13-2 6-phenyl-5-(N⁴-(2-furoyl)-N¹-piperazinyl)-2H-pyridazin-3-one 
• 87769-63-9 5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one 
• 1610354-27-2 1-((3S,4R)-4-(3,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(6-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-4-yl)urea 
• 1610354-61-4 5-amino-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 1610354-60-3 5-azido-6-phenyl-2-(2,2,2-trifluoroethyl)pyridazin-3(2H)-one 
• 126337-04-0 5-azido-6-phenyl-3(2H)-pyridazinone 
• 1204665-46-2 5-methoxy-2-(4-methoxybenzyl)pyridazin-3(2H)-one 
• 1204665-41-7 5-chloro-2-(4-methoxybenzyl)-6-phenylpyridazin-3(2H)-one 
• 1206156-58-2 2-(4-nitrobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-62-8 2-(4-iodobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-57-1 2-(2-nitrobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-63-9 2-(2-methoxybenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 
• 1206156-61-7 2-(2-iodobenzyl)-5-chloro-6-phenylpyridazin-3(2H)-one 

Relevant articles and documents

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition

Three new ureido-pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor AVS-0288, were designed by taking into account the structure-activity relationships determined for several ureido-oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5-aminopyridazinone intermediates (6a and 6b), which molecular structures were confirmed by means of X-ray diffraction data on 6a. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual-luciferase and AlphaScreen-based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5-oxadiazole ring and the extended ZZ arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.

Pyridazines. XV. Synthesis of 6-aryl-5-amino-3(2H)-pyridazinones as potential platelet aggregation inhibitors

Several 3(2H)-pyridazinones with amino groups at the 5-position of the pyridazine nucleus have been prepared. The 6-aryl-5-halo-3(2H)-pyridazinones obtained from mucochloric and mucobromic acid lead to the corresponding 5- alkylamino-3(2H)-pyridazinones,