51689-18-0

Basic information

• Product Name: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, ethyl ester
• Synonyms: Propanoic acid,3-hydroxy-2-(hydroxymethyl)-2-methyl-,ethyl ester
• CAS NO: 51689-18-0
• Molecular Formula: C7H14O4
• Molecular Weight: 162.186
• Mol File: 51689-18-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 106-108 °C(Press: 1.5 Torr)
• Density: 1.137±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, ethyl ester(51689-18-0)
• EPA Substance Registry System: Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-, ethyl ester(51689-18-0)

Safety Data

• Hazardous Substances Data: 51689-18-0(Hazardous Substances Data)

Upstream product

• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 64-17-5 ethanol 

Relevant articles and documents

Selective monobenzylation of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) to yield an AB linear monomer and analogous linear oligomers

The synthesis of a mono-benzylated AB monomer based on bis-MPA is explored and accomplished via a three-step synthesis without column chromatography. This optimized synthesis utilizes a generic acid-catalyzed esterification of bis-MPA to the ethyl ester.

POLYCARBONATES BEARING AROMATIC N-HETEROCYCLES FOR DRUG DELIVERY

Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM

A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.