51690-26-7Relevant articles and documents
A 4,4 '-di-substituted diphenyl ketone compound and its preparation method
-
Paragraph 0039-0041, (2017/04/06)
The invention provides a 4,4'-dibasic benzophenone compound which has a structure shown in the following formula I. The compound can well inhibit activities of an AP-1 protein and an NDM-1 protein and has the IC50 value of 52.93 plus and minus 11.86muM fo
Derivatization of coumarins at the benzenoid ring in aqueous medium
Bhunia, Sankar C.,Pal, Sutanuka,Patra, Gopal C.,Pal, Sudhir C.
, p. 1679 - 1688 (2015/02/02)
Some 6-disubstituted, 8-disubstituted, and/6,8-disubstituted compounds have been prepared from coumarin, 7-methylcoumarin, and 3,4-benzocoumarin. The Reimer-Tiemann reaction, Lederer-Manasse reaction, bromination using molecular bromine as well as 2,4,4,6-tetrabromocyclohex-2,5-dien-1-one, Elbs reaction, and diazocoupling have been carried under controlled conditions to obtain various derivatives. Further, several reactions of aldehyde derivatives of these coumarins have been carried on to prepare important functional compounds including some heterocycles. It is noteworthy that these aldehydes behave as phenolic aldehydes under alkaline conditions to undergo the Dakin reaction. The reactions are mostly carried in aqueous media involving a dianionic intermediate and hence fulfill one important criterion of green chemistry.
IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides
Moorthy, Jarugu Narasimha,Neogi, Ishita
supporting information; experimental part, p. 3868 - 3871 (2011/08/06)
A variety of primary alcohols are shown to be converted to the corresponding benzimidazoles in one pot by employing IBX and o-phenylenediamine in DMSO at room temperature. o-Iodobenzoic acid is the end product of IBX, which is employed in 1.0 equiv. Arylmethyl bromides are also shown to be converted likewise to benzimidazoles in moderate yields in one pot, albeit at slightly elevated temperatures.