51703-58-3 Usage
Description
(RS)-Phenylglycinamide hydrochloride is a chemical compound derived from phenylglycine, an amino acid that is prevalent in peptides and proteins. This hydrochloride salt form enhances the compound's stability and solubility in water, facilitating its use in pharmaceutical and research applications. As a crucial chemical for studying the role of phenylglycine derivatives in biological and chemical processes, (RS)-phenylglycinamide hydrochloride is instrumental in the synthesis of pharmaceuticals and in biochemical and pharmacological research.
Uses
Used in Pharmaceutical Synthesis:
(RS)-Phenylglycinamide hydrochloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its role is to provide a stable and soluble building block that can be easily incorporated into the development of new drugs.
Used in Biochemical and Pharmacological Studies:
In the field of biochemical and pharmacological research, (RS)-phenylglycinamide hydrochloride is used as a research tool to investigate the function and interactions of amino acids and related compounds. Its application aids in understanding the complex roles these molecules play in biological systems.
Used in Chemical Process Research:
(RS)-Phenylglycinamide hydrochloride is also utilized in the study of chemical processes involving phenylglycine derivatives. Its application in this context helps researchers gain insights into the behavior and properties of these compounds, which can be crucial for the development of new chemical methodologies and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 51703-58-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,0 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51703-58:
(7*5)+(6*1)+(5*7)+(4*0)+(3*3)+(2*5)+(1*8)=103
103 % 10 = 3
So 51703-58-3 is a valid CAS Registry Number.
51703-58-3Relevant articles and documents
Enzymatic synthesis of chiral phenylalanine derivatives by a dynamic kinetic resolution of corresponding amide and nitrile substrates with a multi-enzyme system
Yasukawa, Kazuyuki,Asano, Yasuhisa
, p. 3327 - 3332 (2013/01/15)
Mutant α-amino-ε-caprolactam (ACL) racemase (L19V/L78T) from Achromobacter obae with improved substrate specificity toward phenylalaninamide was obtained by directed evolution. The mutant ACL racemase and thermostable mutant D-amino acid amidase (DaaA) from Ochrobactrum anthropi SV3 co-expressed in Escherichia coli (pACLmut/pDBFB40) were utilized for synthesis of (R)-phenylalanine and non-natural (R)-phenylalanine derivatives (4-OH, 4-F, 3-F, and 2-F-Phe) by dynamic kinetic resolution (DKR). Recombinant E. coli with DaaA and mutant ACL racemase genes catalyzed the synthesis of (R)-phenylalanine with 84% yield and 99% ee from (RS)-phenylalaninamide (400 mM) in 22 h. (R)-Tyrosine and 4-fluoro-(R)-phenylalanine were also efficiently synthesized from the corresponding amide compounds. We also co-expresed two genes encoding mutant ACL racemase and L-amino acid amidase from Brevundimonas diminuta in E. coli and performed the efficient production of various (S)-phenylalanine derivatives. Moreover, 2-aminophenylpropionitrile was converted to (R)-phenylalanine by DKR using a combination of the non-stereoselective nitrile hydratase from recombinamt E. coli and mutant ACL racemase and DaaA from E. coli encoding mutant ACL racemase and DaaA genes. Copyright
CONVERSION OF α-AMINONITRILES TO AMIDES BY A NEW PINNER TYPE REACTION
Lee, Young Bok,Goo, Yang Mo,Lee, Youn Young,Lee, Jae Keun
, p. 1169 - 1170 (2007/10/02)
α-Aminonitriles were converted exclusively to the amides by 2-mercaptoethanol in anhydrous THF at -78 deg C by bubbling dry HCl gas.
