5175-26-8 Usage
Description
2-Nitronicotinaldehyde is a chemical compound that belongs to the class of nitro-compounds. It is an aldehyde derivative of nicotinic acid and is known for its diverse range of applications in industry and research. Due to its nitro group, 2-nitronicotinaldehyde has potential applications as a precursor in the synthesis of nitroxide radicals, which are widely used in organic synthesis and as spin labels in biological research. Additionally, it can also act as a ligand in the coordination chemistry of transition metals, making it an important compound in the field of inorganic chemistry.
Uses
Used in Pharmaceutical and Agrochemical Industries:
2-Nitronicotinaldehyde is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its versatile chemical properties allow it to be incorporated into a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Organic Synthesis:
2-Nitronicotinaldehyde is used as a precursor in the synthesis of nitroxide radicals, which are important intermediates in organic synthesis. These radicals can be used to mediate various chemical reactions, such as polymerization and oxidation, and can also be employed as spin labels in biological research.
Used in Inorganic Chemistry:
2-Nitronicotinaldehyde can act as a ligand in the coordination chemistry of transition metals. This allows it to form complexes with various metal ions, which can have interesting properties and applications in catalysis, materials science, and other areas of inorganic chemistry.
Overall, 2-nitronicotinaldehyde is a versatile and valuable chemical with a wide range of potential applications in various scientific and industrial fields.
Check Digit Verification of cas no
The CAS Registry Mumber 5175-26-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,7 and 5 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5175-26:
(6*5)+(5*1)+(4*7)+(3*5)+(2*2)+(1*6)=88
88 % 10 = 8
So 5175-26-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N2O3/c9-4-5-2-1-3-7-6(5)8(10)11/h1-4H
5175-26-8Relevant articles and documents
Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis: Design, in silico physicochemical and SAR studies of 2-aminoquinoline-3-carboxamides
Yuan, Pengtao,Gu, Xiangyu,Ni, Xintong,Qi, Yingxue,Shao, Xusheng,Xu, Xiaoyong,Liu, Jianwen,Qian, Xuhong
supporting information, (2021/09/22)
Malignant gliomas are the most common brain tumors, with generally dismal prognosis, early clinical deterioration and high mortality. Recently, 2-aminoquinoline scaffold derivatives have shown pronounced activity in central nervous system disorders. We herein reported a series of 2-aminoquinoline-3-carboxamides as novel non-alkylator anti-glioblastoma agents. The synthesized compounds showed comparable activity to cisplatin against glioblastoma cell line U87 MG in vitro. Among them, we found that 6a displayed good inhibitory activity against A172 and U118 MG glioblastoma cell lines and induced cell cycle arrest in the G2/M phase and apoptosis in U87 MG by flow cytometry analysis. Additionally, 6a displayed low cytotoxicity to several normal human cell lines. In silico study showed 6a had promising physicochemical properties and was predicted to cross the blood–brain barrier. Moreover, preliminary structure–activity relationships are also investigated, shedding light on further modifications towards more potent agents on this series of compounds. Our results suggest this compound has a promising potential as an anti-glioblastoma agent with a differential effect between tumor and non-malignant cells.