51751-37-2Relevant articles and documents
Access to chromone-3-carboxylic acid via silver mediated coupling of 4-hydroxy coumarin and enol ester
Mishra, Priyadarshini,Sepay, Nayim,Panda, Niranjan
, (2021)
A silver-mediated aerobic approach to access 2-methyl-chromone-3-carboxylic acid from the reaction of 4-hydroxy coumarin and enol ester in the presence of base has been presented. Mechanistic investigation suggests that the base induced Michael-type addition reaction of 4-hydroxy coumarin to the enol ester resulting the sequential ring opening and closing with the liberation of acetone are the key-steps for the overall transformation. Theoretical calculation of energy of the intermediates by DFT supports the proposed reaction mechanism.
An Improved Synthesis of 2-Methylchromone-3-carboxylic Acid and its Esters
Coppola, Gary M.,Dodsworth, Roy W.
, p. 523 - 524 (2007/10/02)
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Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids useful for preventing asthmatic symptoms
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, (2008/06/13)
Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids having the structural formula: SPC1 Wherein R1 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or acyloxy; R2 represents hydrogen, lower alkyl, fluorinated lower alkyl, alkoxycarbonyl, carboxy, or lower alkyl carboxylic acid; Z represents cyano, carboxy, alkoxycarbonyl, or EQU1 wherein X represents amino, N-lower-alkylamino, hydroxylamino, N-lower-alkylhydroxylamino, ureido, piperidino, or anilino, with the proviso that when R2 represents hydrogen, Z represents cyano or EQU2 wherein X has the same meaning as given above; and wherein R2 and Z together may form a substituted pyrrole ring; and the corresponding non-toxic, pharmaceutically acceptable salts.