51768-57-1

Basic information

• Product Name: Benzene, 1-butyl-3,5-dimethoxy-
• CAS NO: 51768-57-1
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol File: 51768-57-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzene, 1-butyl-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-butyl-3,5-dimethoxy-(51768-57-1)
• EPA Substance Registry System: Benzene, 1-butyl-3,5-dimethoxy-(51768-57-1)

Safety Data

• Hazardous Substances Data: 51768-57-1(Hazardous Substances Data)

Upstream product

• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 1254840-39-5 (E)-1-(2-bromovinyl)-3,5-dimethoxybenzene 
• 2386-64-3 ethylmagnesium chloride 
• 126395-80-0 1-butyl-3,5-dimethylcyclohexa-2,5-diene-1-carboxylic acid 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 927-77-5 n-propylmagnesium bromide 
• 708253-29-6 1-(3,5-dimethoxyphenyl)butan-1-ol 
• 85696-70-4 5-(but-3-enyl)-3-methoxycyclohex-2-enone 
• 542-69-8 1-iodo-butane 

Downstream Products

• 69505-81-3 5-Butyl-2-hexylresorcin 
• 1197155-74-0 1,5-dimethoxy-3-butylcyclohexa-1,4-diene 
• 70680-18-1 5-Butyl-2-pentylresorcin 
• 88640-67-9 mono ether of 5-n-butylresorcinol 
• 46113-76-2 5-n-butyl-1,3-dihydroxybenzene 

Relevant articles and documents

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Cannabidiol is one of the main non-psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55–59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).

Efficient Pd-Catalyzed Direct Coupling of Aryl Chlorides with Alkyllithium Reagents

Organolithium compounds are amongst the most important organometallic reagents and frequently used in difficult metallation reactions. However, their direct use in the formation of C?C bonds is less established. Although remarkable advances in the coupling of aryllithium compounds have been achieved, Csp2?Csp3 coupling reactions are very limited. Herein, we report the first general protocol for the coupling or aryl chlorides with alkyllithium reagents. Palladium catalysts based on ylide-substituted phosphines (YPhos) were found to be excellently suited for this transformation giving high selectivities at room temperature with a variety of aryl chlorides without the need for an additional transmetallation reagent. This is demonstrated in gram-scale synthesis including building blocks for materials chemistry and pharmaceutical industry. Furthermore, the direct coupling of aryllithiums as well as Grignard reagents with aryl chlorides was also easily accomplished at room temperature.

PHENYL-UREA AND PHENYL-CARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION

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