51777-15-2 Usage
Description
4-(DiMethylaMinoethoxy)benzophenone is a chemical compound derived from benzophenone, featuring a dimethylaminoethoxy group at the 4-position. It is known for its photo-degradation properties and has been identified as a product of the drug Tamoxifen, which is a selective estrogen response modifier (SERM), protein kinase C inhibitor, and anti-angiogenetic factor.
Uses
Used in Pharmaceutical Industry:
4-(DiMethylaMinoethoxy)benzophenone is used as a photo-degradation product for Tamoxifen (T006000), which is a medication with multiple applications in the treatment of various conditions. As a SERM, it can be employed for hormone regulation, while its protein kinase C inhibitor and anti-angiogenetic properties make it useful in the treatment of certain cancers by inhibiting cell growth and blood vessel formation.
Used in Research and Development:
In the field of research and development, 4-(DiMethylaMinoethoxy)benzophenone serves as a valuable compound for studying the degradation of Tamoxifen and its potential effects on the drug's efficacy and safety. This knowledge can contribute to the development of improved drug formulations and delivery systems, as well as a better understanding of the drug's mechanism of action.
Used in Quality Control and Analysis:
4-(DiMethylaMinoethoxy)benzophenone can be utilized in the quality control and analysis of Tamoxifen and its formulations. By monitoring the presence and concentration of this compound, researchers and pharmaceutical companies can ensure the stability, purity, and overall quality of Tamoxifen products, ultimately contributing to their safety and effectiveness for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 51777-15-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,7 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 51777-15:
(7*5)+(6*1)+(5*7)+(4*7)+(3*7)+(2*1)+(1*5)=132
132 % 10 = 2
So 51777-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO2/c1-18(2)12-13-20-16-10-8-15(9-11-16)17(19)14-6-4-3-5-7-14/h3-11H,12-13H2,1-2H3
51777-15-2Relevant articles and documents
Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols
Annatelli, Mattia,Trapasso, Giacomo,Salaris, Claudio,Salata, Cristiano,Castellano, Sabrina,Aricò, Fabio
supporting information, p. 3459 - 3464 (2021/05/24)
N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
Carpenter, Colleen,Sorenson, Roderick J.,Jin, Yafei,Klossowski, Szymon,Cierpicki, Tomasz,Gnegy, Margaret,Showalter, Hollis D.
, p. 5495 - 5504 (2016/10/24)
The clinical selective estrogen receptor modulator tamoxifen is also a modest inhibitor of protein kinase C, a target implicated in several untreatable brain diseases such as amphetamine abuse. This inhibition and tamoxifen's ability to cross the blood br
Wittig-Horner approach for the synthesis of tamoxifen
Pandey, Rajesh K.,Wakharkar,Kumar, Pradeep
, p. 2795 - 2800 (2007/10/03)
A stereoselective synthesis of Z-tamoxifen, a tetra-substituted alkene with antiestrogenic activity, is described. The Wittig-Horner reaction has been employed as the key step to establish the olefin stereochemistry. Copyright Taylor & Francis, Inc.
