51788-77-3

Basic information

• Product Name: 2',4',6'-TRIFLUOROACETOPHENONE
• Synonyms: 2',4',6'-TRIFLUOROACETOPHENONE;2,4,6-TRIFLUOROACETOPHENONE;1-(2,4,6-TRIFLUORO-PHENYL)-ETHANONE;2',4',6'-Trifluoroacetophenone 97%;2',4',6'-Trifluoroacetophenone97%;1-(2,4-difluorophenyl)-2-fluoroethan-1-one
• CAS NO: 51788-77-3
• Molecular Formula: C₈H₅F₃O
• Molecular Weight: 174.12
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Miscellaneous;Ketone
• Mol File: 51788-77-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 190°C
• Flash Point: 62.1 °C
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 0.961mmHg at 25°C
• Refractive Index: 1.473
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2',4',6'-TRIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4',6'-TRIFLUOROACETOPHENONE(51788-77-3)
• EPA Substance Registry System: 2',4',6'-TRIFLUOROACETOPHENONE(51788-77-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 51788-77-3(Hazardous Substances Data)

Usage

Description

2',4',6'-Trifluoroacetophenone is an organic compound characterized by the presence of three fluorine atoms at the 2', 4', and 6' positions of the acetophenone molecule. It is a colorless to pale yellow liquid with a distinct aromatic odor. 2',4',6'-TRIFLUOROACETOPHENONE is known for its reactivity and is commonly used as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
2',4',6'-Trifluoroacetophenone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique fluorinated structure allows for the development of new drugs with improved properties, such as enhanced bioavailability, increased stability, and better target selectivity.
Used in Chemical Industry:
In the chemical industry, 2',4',6'-Trifluoroacetophenone serves as a versatile building block for the synthesis of a wide range of organic compounds, including agrochemicals, dyes, and advanced materials. Its reactivity and the presence of fluorine atoms make it an attractive candidate for the development of new products with improved performance characteristics.
Used in Synthesis of Fluorinated Heterocycles:
2',4',6'-Trifluoroacetophenone is used as a reactant in the synthesis of various fluorinated heterocycles, such as 4,6-and 6,7-difluoro-3-methyl-1H-indazoles. These compounds exhibit interesting biological activities and have potential applications in the development of new drugs and pharmaceutical agents.

InChI:InChI=1/C8H5F3O/c1-4(12)8-6(10)2-5(9)3-7(8)11/h2-3H,1H3

Upstream product

• 372-38-3 1,3,5-trifluorobenzene 
• 108-24-7 acetic anhydride 
• 2367-76-2 2,4,6-trifluorobromobenzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1196958-94-7 tert-butyl (1S,4S)-5-(2-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 
• 1203552-14-0 C₁₅H₈F₆O₂ 
• 1632285-92-7 1-(2-amino-4,6-difluorophenyl)ethanone 
• 1186334-90-6 (1S,4S)-tert-butyl 5-(4-((E)-3-(dimethylamino)acryloyl)-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 
• 1250113-83-7 1-(2,4,6-trifluorophenyl)ethan-1-ol 
• 1094405-83-0 4-(2,4,6-trifluorophenyl)thiazol-2-amine 
• 746630-36-4 2-bromo-1-(2,4,6-trifluorophenyl)ethan-1-one 
• 1329167-03-4 4,6-difluoro-1,3-dimethyl-1H-indazole 
• 1147939-78-3 2-(2,4,6-trifluorophenyl)-2-methyloxirane 
• 1186334-89-3 tert-butyl (1S,4S)-5-(4-acetyl-3,5-difluorophenyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PHENYL KETONES

The present invention relates to a process for the preparation of phenyl ketones and the preparation of phenoxyphenyl derivatives.

Studies in Fluorinated 1,3-diketones and related compounds part X. Synthesis of some New polyfluorinated 1,3-diketones, their copper 1,3-diketonates and Spectral Studies

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