517920-69-3

Basic information

• Product Name: 5-BROMO-2,3-DIAMINOFLUOROBENZENE
• Synonyms: 5-BROMO-2,3-DIAMINOFLUOROBENZENE;5-Bromo-3-fluorobenzene-1,2-diamine;5-Bromo-3-fluoro-1,2-benzenediamine;5-Bromo-3-fluorobenzene-1,2-diamine 97%;5-Bromo-3-fluorophenylene-1,2-diamine, 5-Bromo-2,3-diamino-1-fluorobenzene;1, 2- Benzenediamine, 5- bromo- 3- fluoro-;5-Bromo-3-fluorobenzene-1,2-diamine97%
• CAS NO: 517920-69-3
• Molecular Formula: C₆H₆BrFN₂
• Molecular Weight: 205.03
• Mol File: 517920-69-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 274.8°C at 760 mmHg
• Flash Point: 120°C
• Appearance: /
• Density: 1.792g/cm³
• Vapor Pressure: 0.0053mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Room temperature.
• PKA: 2.07±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2,3-DIAMINOFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIAMINOFLUOROBENZENE(517920-69-3)
• EPA Substance Registry System: 5-BROMO-2,3-DIAMINOFLUOROBENZENE(517920-69-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 517920-69-3(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,3-diaminofluorobenzene is a chemical compound with the molecular formula C6H5BrF2N2. It is a derivative of fluorobenzene and contains both bromine and amino groups. 5-BROMO-2,3-DIAMINOFLUOROBENZENE is commonly used in the synthesis of pharmaceutical products, agrochemicals, and dyes. It has also been studied for its potential use as a reagent in organic chemistry reactions and as a building block for the preparation of various organic compounds. Additionally, 5-Bromo-2,3-diaminofluorobenzene has been investigated for its potential biological and pharmacological activities, making it an important compound in both research and industrial applications.

InChI:InChI=1/C6H6BrFN2/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,9-10H2

Upstream product

• 517920-70-6 4-Bromo-2-fluoro-6-nitrobenzenamine 
• 1193385-18-0 2-amino-4-bromo-6-fluoro-nitrobenzene 

Downstream Products

• 1210048-05-7 7-bromo-5-fluoroquinoxaline 
• 1242088-28-3 C₃₆H₄₁FN₆O₄ 
• 1197944-23-2 6-bromo-4-fluoro-1H-benzo[d]imidazole 

Relevant articles and documents

Aromatic-ring-containing compound, preparation method thereof, pharmaceutical composition and application thereof

The invention discloses an aromatic-ring-containing compound, a preparation method thereof, a pharmaceutical composition and application. The present invention provides the aromatic-ring-containing compound represented by a formula 1, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or a solvate thereof, and the aromatic-ring-containing compound can be effectively bounded to bromodomains of BRD4, BRD3, BRD2, and BRDT in BET family to regulate transcription of downstream gene c-myc and related target genes of the c-myc so as to regulate downstream signalingpathways to play specific roles including treatment of diseases such as inflammatory diseases, cancer, and AIDS. Some of the compounds have high activity, and have good cell activity and metabolic stability, so that the compounds can be an effective drug for treating tumors.

SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

Inhibitors of Rho kinase have been developed based on two distinct scaffolds, benzimidazoles, and benzoxazoles. SAR studies and efforts to optimize the initial lead compounds are described. Novel selective inhibitors of ROCK-II with excellent potency in b