51793-90-9

Basic information

• Product Name: NAPHTHO[1,2-D][1,3]OXAZOLE-2-THIOL
• Synonyms: NAPHTHO[1,2-D][1,3]OXAZOLE-2-THIOL
• CAS NO: 51793-90-9
• Molecular Formula: C₁₁H₇NOS
• Molecular Weight: 201.24
• Mol File: 51793-90-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 363.8°C at 760 mmHg
• Flash Point: 173.8°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.76E-05mmHg at 25°C
• Refractive Index: 1.786
• CAS DataBase Reference: NAPHTHO[1,2-D][1,3]OXAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: NAPHTHO[1,2-D][1,3]OXAZOLE-2-THIOL(51793-90-9)
• EPA Substance Registry System: NAPHTHO[1,2-D][1,3]OXAZOLE-2-THIOL(51793-90-9)

Safety Data

• Hazardous Substances Data: 51793-90-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7NOS/c14-11-12-10-8-4-2-1-3-7(8)5-6-9(10)13-11/h1-6H,(H,12,14)

Upstream product

• 2834-92-6 1-amino-2-naphthol 
• 842-07-9 Sudan I 
• 140-89-6 potassium ethyl xanthogenate 
• 75-15-0 carbon disulfide 
• 1198-27-2 1-aminonaphthalene-2-ol hydrochloride 

Downstream Products

• 74322-45-5 2-(3-chloro-4-nitro-phenylsulfanyl)-naphtho[1,2-d]oxazole 
• 74322-46-6 2-(3-bromo-4-nitro-phenylsulfanyl)-naphtho[1,2-d]oxazole 
• 7783-06-4 hydrogen sulfide 
• 2834-92-6 1-amino-2-naphthol 
• 74322-59-1 2-(2-bromo-benzylsulfanyl)-naphtho[1,2-d]oxazole 
• 72234-83-4 2-(2-nitro-phenyl)-naphtho[1,2-d]oxazole-5-thiosulfonic acid S-naphtho[1,2-d]oxazol-2-yl ester 
• 72246-09-4 2-(3-nitro-phenyl)-naphtho[1,2-d]oxazole-5-thiosulfonic acid S-naphtho[1,2-d]oxazol-2-yl ester 
• 4410-27-9 2-methylsulfanyl-naphtho[1,2-d]oxazole 
• 199293-01-1 2-(4-methyl-1-homopiperazinyl)naphtho[1,2-d]oxazole 
• 74322-62-6 2-(2,4-dinitro-benzenesulfonyl)-naphtho[1,2-d]oxazole 
• 83557-12-4 N-(4-Methoxy-phenyl)-2-(naphtho[1,2-d]oxazol-2-ylsulfanyl)-acetamide 

Relevant articles and documents

Regioselective thiolation of arenes and heteroarenes: C-H functionalization strategy for C-S bond formation

A facile transition-metal-free oxidative cross-dehydrogenative coupling reaction involving selective formation of a C-S bond leading to the synthesis of arylthiobenzoxazoles, heteroarylthiobenzoxazoles, and arylthiobenzothiazoles has been described. This highly regioselective C-H functionalization reaction with electron-rich aromatic systems including heteroaromatics is achieved by reversing the reactivity of sulfur in the presence of a suitable oxidant and strong acid. (Chemical Equation Presented).

Pharmaceutical composition for the treatment of CNS and other disorders

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharma

Serotonin 5-HT3 receptor partial activator

This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.