51794-07-1Relevant articles and documents
Preparation method of 2,5-diamino phenethyl alcohol
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Paragraph 0020-0022; 0029-0031; 0038-0040; 0047-0058, (2018/04/21)
The invention discloses a preparation method of 2,5-diamino phenethyl alcohol. The method comprises the following steps that prepared 5-nitro-2-amino-benzene acetic acid is dissolved into diethyl ether, FeCl3 and MnO2 are added, nitrogen is introduced, th
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors
Hasvold, Lisa A.,Wang, Le,Przytulinska, Magdalena,Xiao, Zhan,Chen, Zehan,Gu, Wen-Zhen,Merta, Philip J.,Xue, John,Kovar, Peter,Zhang, Haiying,Park, Chang,Sowin, Thomas J.,Rosenberg, Saul H.,Lin, Nan-Horng
, p. 2311 - 2315 (2008/09/21)
The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.
Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamatesf
Sykes, Bridget M.,Hay, Michael P.,Bohinc-Herceg, Dubravka,Helsby, Nuala A.,O'Connor, Charmian J.,Denny, William A.
, p. 1601 - 1608 (2007/10/03)
The rates and extent of release of a series of substituted anilines from 4-nitrobenzyl carbamates, following nitro group reduction by radiolytic, enzymic and chemical methods, are reported. The yield of released anilines decreased over the pH range 4-7, b
