51795-88-1Relevant articles and documents
Odd-numbered very-long-chain polyunsaturated fatty acids from the dinoflagellate Amphidinium carterae identified by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry
Rezanka, Tomas,Nedbalova, Linda,Sigler, Karel
, p. 2849 - 2855 (2008)
A method is described for the enrichment of odd very-long-chain polyunsaturated fatty acids (VLCPUFAs) by means of RP-HPLC and argentation TLC from total fatty acids of the dinoflagellate A. carterae and their identification as picolinyl esters by means of microbore liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization (LC-MS/APCI). The combination of argentation TLC and LC-MS/APCI was used to identify rare and unusual odd VLCPUFAs up to nonacosahexaenoic acid. Two acids, (allZ)-nonacosa-11,14,17,20,23-pentaenoic acid (29:5n-6) and (allZ)-nonacosa-11,14,17,20,23,26-hexaenoic acid (29:6n-3), were synthesized for the first time to unambiguously confirm their structure. Possible biosynthetic pathways for odd VLCPUFAs are also proposed.
Synthesis of a natural insect repellent isolated from thrips
Csuk, René,Niesen, Anja,Tschuch, Gunther,Moritz, Gerald
, p. 6001 - 6004 (2004)
A convenient, high yield procedure for the synthesis of (11Z)-11,19-eicosadienyl acetate (1) has been developed. This compound shows strong repellent activity against ants.
Synthesis of (±)duryne+
Deshpande,Upadhye,Wakharkar
, p. 1991 - 1992 (1989)
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Enzymatic Desymmetrization of a Prochiral 1,3,5-Pentanetriol Derivative. Application to the Synthesis of a Cyanobacterial Heterocyst Glycolipid
Soriente, Annunziata,Laudisio, Giovanna,Giordano, Maurizio,Sodano, Guido
, p. 859 - 862 (1995)
(R)-3-t-butyldimethylsilyloxy-5-acetoxy-1-pentanol has been obtained by PFL catalyzed hydrolysis of the corresponding diacetate and has been utilized for the formal synthesis of the most widespread heterocyst glycolipid of N2-fixing cyanobacteria.
4,4,16-Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation
Colombano, Alessandro,Dall'Angelo, Sergio,Kingston, Lee,Gr?nberg, Gunnar,Correia, Claudia,Passannante, Rossana,Baz, Zuri?e,Morcillo, Miguel ángel,Elmore, Charles S.,Llop, Jordi,Zanda, Matteo
supporting information, p. 2317 - 2331 (2020/10/02)
Fatty acid oxidation (FAO) produces most of the ATP used to sustain the cardiac contractile work, although glycolysis is a secondary source of ATP under normal physiological conditions. FAO impairment has been reported in the advanced stages of heart failure (HF) and is strongly linked to disease progression and severity. Thus, from a clinical perspective, FAO dysregulation provides prognostic value for HF progression, the assessment of which could be used to improve patient monitoring and the effectiveness of therapy. Positron emission tomography (PET) imaging represents a powerful tool for the assessment and quantification of metabolic pathways in vivo. Several FAO PET tracers have been reported in the literature, but none of them is in routine clinical use yet. Metabolically trapped tracers are particularly interesting because they undergo FAO to generate a radioactive metabolite that is subsequently trapped in the mitochondria, thus providing a quantitative means of measuring FAO in vivo. Herein, we describe the design, synthesis, tritium labelling and radiofluorination of 4,4,16-trifluoro-palmitate (1) as a novel potential metabolically trapped FAO tracer. Preliminary PET-CT studies on [18F]1 in rats showed rapid blood clearance, good metabolic stability – confirmed by using [3H]1 in vitro – and resistance towards defluorination. However, cardiac uptake in rats was modest (0.24±0.04 % ID/g), and kinetic analysis showed reversible uptake, thus indicating that [18F]1 is not irreversibly trapped.
Synthetic method of sex pheromone (Z, E) -10 - cetane compound (by machine translation)
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Paragraph 0074-0075, (2019/08/30)
The invention discloses a peach borer sex pheromone (Z. Ω - bromodecanol and dihydropyran react, hydrolyze and deprotect the corresponding acetal, acetal and trialkyl/aryl ester under the action of the catalyst to form E-type main (Z, E) -10 - hexadecene -10 - alcohol and oxidant oxidation reaction to obtain E-form main (Z, E) -1 - hexadecene/aryl ester. E) -10 - cetane/aromatic ester, under the action of a catalyst . E) is a main group E type (Z, E) n-hexylene -1 - alcohol, and the like. E) -10 - cetane dialdehyde. The method is less in side reaction, and high in product purity. (by machine translation)