518-11-6 Usage
Description
DEMECOLCEINE is a colchicine alkaloid derived from the corms and seeds of Colchicum autumnale, Gloriosa virescens, and Littoria modesta. It is a yellow solid that forms colorless rods when crystallized from ethanol and has a specific rotation of [α]D 223° (CHC13).
Uses
Used in Pharmaceutical Industry:
DEMECOLCEINE is used as an antimitotic agent for its ability to disrupt microtubules by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin, which leads to the induction of apoptosis in several normal and tumor cell lines. Additionally, DEMECOLCEINE activates the JNK/SAPK signaling pathway, making it a potential candidate for cancer treatment and other related applications.
Check Digit Verification of cas no
The CAS Registry Mumber 518-11-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 518-11:
(5*5)+(4*1)+(3*8)+(2*1)+(1*1)=56
56 % 10 = 6
So 518-11-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO5/c1-21-14-7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12-6-8-15(22)16(23)10-13(12)14/h6,8-10,14,21H,5,7H2,1-4H3,(H,22,23)/t14-/m0/s1
