518-94-5 Usage
Description
CYCLEANINE is an alkaloid derived from the Triclisia subcordata Oliv (Menispermeaceae), a medicinal plant that is traditionally used to treat various diseases in West Africa. It is known for its in-vitro anti-ovarian cancer activity, making it a potential candidate for pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
CYCLEANINE is used as an anti-cancer agent for its in-vitro anti-ovarian cancer activity. It demonstrates potential in treating ovarian cancer by targeting and inhibiting the growth of cancer cells.
Used in Traditional Medicine:
In West Africa, CYCLEANINE is used as a traditional medicine for treating various diseases due to its medicinal properties derived from the Triclisia subcordata Oliv plant.
Check Digit Verification of cas no
The CAS Registry Mumber 518-94-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 518-94:
(5*5)+(4*1)+(3*8)+(2*9)+(1*4)=75
75 % 10 = 5
So 518-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C38H42N2O6/c1-39-16-14-25-21-32(42-4)36(44-6)38-33(25)29(39)19-23-10-12-27(13-11-23)45-37-34-26(22-31(41-3)35(37)43-5)15-17-40(2)30(34)20-24-8-7-9-28(18-24)46-38/h7-13,18,21-22,29-30H,14-17,19-20H2,1-6H3/t29-,30-/m1/s1
518-94-5Relevant articles and documents
Synthesis of cycleanine mono-N-oxides
Kashiwaba,Oho,Toda,Suzuki,Sano
, p. 253 - 255 (2007/10/03)
Oxidation of cycleanine (3) with m-chloroperbenzoic acid gave two diastereomeric N-oxides (1 and 2), and their stereochemistry was unambiguously determined on the basis of spectroscopic evidence. The NMR spectra of synthetic cycleanine mono-N-oxides 1 and 2 were significantly different from those of the natural product previously reported to be cycleanine N-oxide.
THE BIOSYNTHESIS OF THE ALKALOIDS OF CISSAMPELOS PAREIRA LINN
Bhakuni,Dewan S.,Jain,Sudha,Chaturvedi,Rekha
, p. 3975 - 3982 (2007/10/02)
Tracer experimets show that the bisbenzylisoqunoline alkaloid,(S,R)-hayatidin (10) is stereospecifically biosynthesized in young Cissampelos pareira Linn plants by intermolecular oxidativ coupling of (S)-(5)-and (R)-(3)-N-methylcoclaurines whereas (R,R)-isochondrodendrine (14) and (R,R)-bebeerine (12) are formed in the plants by oxidative dimerization of (R)-N-methyl-coclaurine (3).