518054-59-6

Basic information

• Product Name: [(4-{[(4-chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)sulfanyl]acetic acid
• Synonyms: [(4-{[(4-chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)sulfanyl]acetic acid
• CAS NO: 518054-59-6
• Molecular Formula: C₁₈H₁₄ClNO₅S₂
• Molecular Weight: 423.89046
• Mol File: 518054-59-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(4-{[(4-chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)sulfanyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-{[(4-chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)sulfanyl]acetic acid(518054-59-6)
• EPA Substance Registry System: [(4-{[(4-chlorophenyl)sulfonyl]amino}-1-hydroxy-2-naphthyl)sulfanyl]acetic acid(518054-59-6)

Safety Data

• Hazardous Substances Data: 518054-59-6(Hazardous Substances Data)

Upstream product

• 1429765-70-7 2-iodo-1-methoxy-4-nitronaphthalene 
• 4900-63-4 1-methoxy-4-nitronaphthalene 
• 1429765-71-8 methyl 2-((1-methoxy-4-nitronaphthalen-2-yl)thio)acetate 
• 1429765-78-5 methyl 2-((4-amino-1-methoxynaphthalen-2-yl)thio)acetate 
• 1429765-80-9 methyl 2-((4-(4-chlorophenylsulfonamido)-1-methoxynaphthalen-2-yl)thio )acetate 
• 107379-25-9 4-chloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)benzenesulfonamide 
• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 98-64-6 4-Chlorobenzenesulfonamide 

Relevant articles and documents

Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors

A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed. These PIs bearing 4-aromatic sulfonyl naphthalene-based scaffold and Leu-boronic moiety as covalent bonding group displayed f

SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.