518070-28-5

Basic information

• Product Name: 2-FLUORO-4-METHYLPHENYLACETIC ACID
• Synonyms: 2-FLUORO-4-METHYLPHENYLACETIC ACID;RARECHEM AL BO 2244;4-(Carboxymethyl)-3-fluorotoluene;2-Fluoro-4-methylbenzeneacetic acid;2-(2-Fluoro-4-methylphenyl)acetic acid;2-Fluoro-4-methyl phenylace/2-Fluoro-4-methylphenylacetic acid
• CAS NO: 518070-28-5
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.16
• Mol File: 518070-28-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 277.4°C at 760 mmHg
• Flash Point: 121.6°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.00218mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Slightly Soluble (1.0 g/L) (25°C).
• PKA: 4.11±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHYLPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHYLPHENYLACETIC ACID(518070-28-5)
• EPA Substance Registry System: 2-FLUORO-4-METHYLPHENYLACETIC ACID(518070-28-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 518070-28-5(Hazardous Substances Data)

Usage

Uses

As intermediates. Commonly used laboratory reagent. Used in the field of nanoparticles.

InChI:InChI=1/C9H9FO2/c1-6-2-3-7(5-9(11)12)8(10)4-6/h2-4H,5H2,1H3,(H,11,12)

Upstream product

• 146137-80-6 2-fluoro-4-methylbenzaldehyde 
• 452-80-2 2-fluoro-4-methylaniline 
• 1241405-22-0 (2-fluoro-4-methylphenyl)acetaldehyde 

Downstream Products

• 1241405-26-4 methyl (2-fluoro-4-methylphenyl)acetate 
• 1241405-27-5 methyl 2-(2-fluoro-4-methylphenyl)propanoate 
• 1241405-31-1 methyl 2-[4-(bromomethyl)-2-fluorophenyl]propanoate 
• 1241405-35-5 methyl 2-(2-fluoro-4-[(1-methoxycarbonyl-2-oxocyclopentyl)methyl]phenyl)propanoate 
• 1241405-00-4 2-(2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl)propanoic acid 

Relevant articles and documents

Loxoprofen derivative

The invention provides a Loxoprofen derivative. Gastrointestinal tract side effects are low, and the bioavailability can be improved.

Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl) methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities

We previously proposed that membrane permeabilization activity of NSAIDs is involved in NSAID-induced gastric lesions. We here synthesized derivatives of loxoprofen that have lower membrane permeabilization activity than other NSAIDs. Compared to loxoprofen, the derivatives 10a and 10b have lower membrane permeabilization activity and their oral administration produced fewer gastric lesions but showed an equivalent anti-inflammatory effect. These results suggest that 10a and 10b are likely to be therapeutically beneficial as safer NSAIDs.