5182-43-4

Basic information

• Product Name: 1-CHLORO-3- (2-CHLORO-ETHYL)-BENZENE
• Synonyms: 1-CHLORO-3- (2-CHLORO-ETHYL)-BENZENE
• CAS NO: 5182-43-4
• Molecular Formula: C₈H₈Cl₂
• Molecular Weight: 175.06
• Mol File: 5182-43-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CHLORO-3- (2-CHLORO-ETHYL)-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-3- (2-CHLORO-ETHYL)-BENZENE(5182-43-4)
• EPA Substance Registry System: 1-CHLORO-3- (2-CHLORO-ETHYL)-BENZENE(5182-43-4)

Safety Data

• Hazardous Substances Data: 5182-43-4(Hazardous Substances Data)

Usage

Chemical structure

1-Chloro-3-(2-chloro-ethyl)-benzene consists of a benzene ring with two chlorine atoms and an ethyl group attached.

Physical state

It is a colorless liquid.

Odor

It has a faint, sweet odor.

Uses

a. Intermediate in the production of various chemicals such as dyes, pharmaceuticals, and pesticides.
b. Used as a solvent.
c. Used in chemical synthesis.

Hazards

a. May be harmful if inhaled, swallowed, or absorbed through the skin.
b. Exposure can cause irritation to the respiratory system and skin.

Safety precautions

It is important to handle this chemical with care and use appropriate safety precautions when working with it.

Upstream product

• 5182-44-5 2-(3-chlorophenyl)ethanol 
• 26416-24-0 2-(m-chlorophenyl)ethyl tosylate 
• 67-66-3 chloroform 
• 109-89-7 diethylamine 
• 765-46-8 spiro[2.4]hepta-4,6-diene 
• 620-16-6 3-chloroethylbenzene 
• 865-47-4 potassium tert-butylate 
• 6032-29-7 (+/-)-2-pentanol 
• 64-17-5 ethanol 
• 71-23-8 propan-1-ol 
• 67-56-1 methanol 
• 71-36-3 butan-1-ol 
• 67-63-0 isopropyl alcohol 
• 110-58-7 n-Pentylamine 

Downstream Products

• 517914-38-4 1-{2-[3-(1-hydroxycyclohexyl)phenyl]ethyl}-1-cyclohexanol 
• 1025822-45-0 2-{1-[2-(3-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1H-benzoimidazole 
• 34176-92-6 3-chloro-bibenzyl 

Relevant articles and documents

Ketone-catalyzed photochemical C(sp3)–H chlorination

Photoexcited arylketones catalyze the direct chlorination of C(sp3)–H groups by N- chlorosuccinimide. Acetophenone is the most effective catalyst for functionalization of unactivated C–H groups while benzophenone provides better yields for benzylic C–H functionalization. Activation of both acetophenone and benzophenone can be achieved by irradiation with a household compact fluorescent lamp. This light-dependent reaction provides a better control of the reaction as compared to the traditional chlorination methods that proceed through a free radical chain propagation mechanism.

REACTION OF DICHLOROCARBENE WITH SPIROHEPTA-4,6-DIENE

Dichlorocarbene adds to spirohept-4,6-diene with the formation of 6,6-dichlorospiro(bicyclohex-2-ene-4,1'-cyclopropane).When heated the latter undergoes isomerization to 3-(2-chloroethyl)chlorobenzene, and in the presence of nucleophiles (alcohols, amines) it is converted into 3-(2-alkoxyethyl)chlorobenzenes and N-substituted 3-(2-aminoethyl)chlorobenzenes respectively.