51838-06-3

Basic information

• Product Name: 3-(N,N-diphenylamino)-3-oxopropanenitrile
• Synonyms: 3-(N,N-diphenylamino)-3-oxopropanenitrile
• CAS NO: 51838-06-3
• Molecular Weight: 236.273
• Mol File: 51838-06-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-(N,N-diphenylamino)-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N,N-diphenylamino)-3-oxopropanenitrile(51838-06-3)
• EPA Substance Registry System: 3-(N,N-diphenylamino)-3-oxopropanenitrile(51838-06-3)

Safety Data

• Hazardous Substances Data: 51838-06-3(Hazardous Substances Data)

Upstream product

• 68524-31-2 3-(N,N-diphenylamino)-3-oxopropanamide 
• 372-09-8 cyanoacetic acid 
• 122-39-4 diphenylamine 

Downstream Products

• 1150310-09-0 C₂₂H₁₅N₃O₅ 
• 73859-65-1 2-oxo-1-phenylindoline-3-carbonitrile 

Relevant articles and documents

One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N-Aryl Cyanoacetamides

A new one-pot strategy for the synthesis of quinoxalin-2-ones from the tandem nitrosation/cyclization reaction of N-aryl cyanoacetamides with tert-butyl nitrite has been developed. The dehydrogenative N-incorporation is achieved through a sequence of nitrosation, tautomerization, and cyclization, affording quinoxalin-2-ones in moderate to good yields with good functional group tolerance.

Expeditious and Convenient Synthesis of Polycyclic Difluoroboron Complexes of 2-Oxoindoline-3-carboxamides by Tandem Reaction

N-Aryl-2-cyanodiazoacetamides produce polycyclic difluoroboron 2-oxoindoline-3-carboxamide complexes (up to pentacyclic conjugative and fused systems) directly and expeditiously in the presence of boron trifluoride etherate. The boron trifluoride serves as both a catalyst and reactant in the tandem reaction. The tandem reaction includes the carbene aromatic C-H insertion, hydrolysis of the cyano group into an amide group, and boronation of the two amide carbonyl groups. The synthetic method features the advantages of wide substrate scope and excellent chemoselectivity.

Facile and versatile room-temperature synthesis of N,n-disubstituted cyanoacetamides from malonic ester chloride

A general method for the synthesis of various N,N-disubstituted cyanoacetamides from readily available methyl malonyl chloride and secondary amines, including sterically demanding aliphatic and aromatic amines, is described.