519053-87-3

Basic information

• Product Name: 3-amino-2-(4-chloro-2-ethylthio-5-methylbenzenesulphonyl)guanidine
• CAS NO: 519053-87-3
• Molecular Weight: 322.84
• Mol File: 519053-87-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-amino-2-(4-chloro-2-ethylthio-5-methylbenzenesulphonyl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-(4-chloro-2-ethylthio-5-methylbenzenesulphonyl)guanidine(519053-87-3)
• EPA Substance Registry System: 3-amino-2-(4-chloro-2-ethylthio-5-methylbenzenesulphonyl)guanidine(519053-87-3)

Safety Data

• Hazardous Substances Data: 519053-87-3(Hazardous Substances Data)

Relevant articles and documents

Syntheses of a new series of N-amino-N′-(benzenesulphonyl)guanidine derivatives with potential antitumor activity

Syntheses of novel N-amino-N′-(benzenesulphonyl)guanidines (4a-h, 5a-g) from N-(benzenesulphonyl)cyanamide potassium salt and hydrazine derivatives are described. Compounds 4b, 5a-c and 5e were evaluated by in vitro assays of growth inhibition against several human tumor cell lines. The highest in vitro cytotoxic activities were found for 3-phenylamino-1-(2-benzylthio-4-chloro-5-methylbenzenesulphonyl)guanidine (5b) (IC50 = 2.35-8.14 μM) and 3-phenylamino-1-(4-chloro-2-ethoxycarbonylmethylthio-5- methylbenzenesulphonyl)guanidine (5c) (IC50 = 2.74-10.6 μM), while other tested compounds (5a, 5e) showed the moderate cytotoxic activities. The molecular orbital calculation of the possible tautomeric forms of the benzenesulphonylguanidine derivatives were also presented.