519055-62-0

Basic information

• Product Name: Tasisulam
• Synonyms: tasisulam;N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide;Benzamide, N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichloro-;Ly573636;Ly-573636;TS81557;LY573636 (TasisulaM);Tasisulam(Ly-573636
• CAS NO: 519055-62-0
• Molecular Formula: C₁₁H₆BrCl₂NO₃S₂
• Molecular Weight: 415.11
• Product Categories: Inhibitors
• Mol File: 519055-62-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.812
• PKA: 3.45±0.10(Predicted)
• CAS DataBase Reference: Tasisulam(CAS DataBase Reference)
• NIST Chemistry Reference: Tasisulam(519055-62-0)
• EPA Substance Registry System: Tasisulam(519055-62-0)

Safety Data

• Hazardous Substances Data: 519055-62-0(Hazardous Substances Data)

Usage

Description

Tasisulam, also known as its sodium salt form, is a compound with potential antineoplastic activity. It selectively targets tumor cells and is known to induce tumor cell apoptosis through a mitochondrial-targeted mechanism. This process involves the loss of mitochondrial membrane potential and the induction of reactive oxygen species (ROS), making it a promising candidate for cancer treatment.

Uses

Used in Anticancer Applications:
Tasisulam is used as an antineoplastic agent for its selective toxicity towards tumor cells. It is particularly effective in inducing tumor cell apoptosis by targeting the mitochondria, leading to the loss of mitochondrial membrane potential and the induction of reactive oxygen species (ROS). This mechanism contributes to the suppression of tumor growth and progression.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Tasisulam is used as a compound with potential applications in the development of novel cancer treatments. Its unique mechanism of action, targeting mitochondria in tumor cells, makes it a valuable asset in the search for more effective and targeted therapies against various types of cancer.

Upstream product

• 53595-65-6 5-bromo-thiophene-2-sulfonamide 
• 50-84-0 2,4 dichlorobenzoic acid 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 1152981-12-8 2-bromothiophene-5-sulfonyl azide 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 1114547-80-6 N,N'-bis(5-bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzimidamide 

Relevant articles and documents

Improvements of C-H Radio-Iodination of N-Acylsulfonamides toward Implementation in Clinics

An improved protocol to perform C-H radio-iodination is described. These new conditions allow rapid and clean formation of radio-iodinated N-acylsulfonamides using [125 I]NIS and catalytic amounts of palladium acetate and para-toluenesulfonic a

Palladium-Mediated Site-Selective C-H Radio-iodination

The palladium-mediated C-H radio-iodination of arenes using sodium iodide as the primary isotopic source is reported and performed without chemical know-how in 30 min and applied to the synthesis of complex radio-iodinated compounds of biological interest.

N - ((5 - bromo thiophene -2 - yl) sulfonyl) - 2, 4 - dichloro formamide synthetic method (by machine translation)

The invention relates to N - ((5 - bromo thiophene - 2 - yl) sulfonyl) - 2, 4 - dichloro formamide synthetic method, which belongs to the technical field of organic synthesis. The method of the invention comprises the following steps: (1) weigh the raw materials according to the mixture ratio, and the 2, 4 - dichloro formic acid, 2 - bromo thiophene sulfonyl azide is added to the reactor, then sequentially added to the reactor in a small amount of acetonitrile solvent, butyl [...] distal of a cobalt catalyst and, in 60 - 90 °C stirring reaction under the condition of 2 - 6 the H; (2) after the reaction, the reaction product and concentration, sample, utilizing column chromatography separation, to obtain the target product III. The invention through one-step can be to obtain the target product, the synthetic method is simple, short reaction time, without the need for the inert atmosphere, low energy consumption, and the present invention the target product of the one-way yield can reach 76%, high conversion rate of raw materials. In addition, the method of the invention the reaction low equipment requirements, cobalt catalyst cheap raw materials are easy, the industrial cost is low. (by machine translation)