51934-37-3

Basic information

• Product Name: 1-Naphthalenecarboxylic acid, 5-methoxy-
• CAS NO: 51934-37-3
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• Mol File: 51934-37-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Naphthalenecarboxylic acid, 5-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenecarboxylic acid, 5-methoxy-(51934-37-3)
• EPA Substance Registry System: 1-Naphthalenecarboxylic acid, 5-methoxy-(51934-37-3)

Safety Data

• Hazardous Substances Data: 51934-37-3(Hazardous Substances Data)

Usage

Derived from naphthalene

A polycyclic aromatic hydrocarbon

Contains a carboxylic acid group

Adds acidity and reactivity to the compound

Contains a methoxy group

Introduces an electron-donating effect and enhances solubility

Used in pharmaceutical production

For the synthesis of various drugs

Used in organic synthesis

As a building block for other organic compounds

Potential anti-inflammatory properties

May help reduce inflammation in the body

Potential antioxidant properties

May help protect cells from oxidative damage

Potential cancer treatment

Being studied for its possible role in inhibiting cancer growth

Potential treatment for infectious diseases

Being investigated for its possible role in fighting infections.

Upstream product

• 74924-95-1 1-bromo-5-methoxynaphthalene 
• 124-38-9 carbon dioxide 
• 2216-69-5 1-Methoxynaphthalene 
• 16726-67-3 5-bromo-1-naphthalenecarboxylic acid 
• 124-41-4 sodium methylate 
• 86-55-5 1-naphthalenecarboxylic acid 
• 51307-69-8 5-sulfo-1-naphthoic acid 
• 52927-23-8 5-bromo-1-naphthol 
• 61735-56-6 5-iodonaphthalen-1-ol 
• 83-55-6 5-amino-1-naphthol 
• 59866-97-6 5-bromo-1-naphthoic acid methyl ester 
• 91903-16-1 methyl 5-methoxy-1-naphthoic acid 
• 61735-51-1 1-iodo-5-methoxynaphthalene 
• 20816-78-8 5-Cyano-2-naphthol 

Downstream Products

• 110174-18-0 (1R,2R,4S)-2-Ethyl-2-hydroxy-5-methoxy-4-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester 
• 110174-18-0 (1S,2S,4R)-2-Ethyl-2-hydroxy-5-methoxy-4-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester 
• 110173-99-4 (4R,5R)-4-Methoxymethyl-2-(5-methoxy-naphthalen-1-yl)-5-phenyl-4,5-dihydro-oxazole 
• 110174-06-6 1-<(benzyloxy)methyl>-2-acetyl-2-hydroxy-5-methoxy-1,2-dihydronaphthalene 
• 110174-07-7 1-<(benzyloxy)methyl>-2-acetyl-2-hydroxy-5-methoxy-1,2,3,4-tetrahydronaphthalene 
• 110174-08-8 (1R,2S)-1-Benzyloxymethyl-2-(1-hydroxy-ethyl)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 110174-12-4 1-<(benzyloxy)methyl>-2-ethyl-2-hydroxy-5-methoxy-1,2,3,4-tetrahydronaphthalene 
• 110174-05-5 (+)-trans-1-<(benzyloxy)methyl>-2-vinyl-5-methoxy-1,2-dihydronaphthalene 
• 99797-36-1 1-<(S,S)-4-(methoxymethyl)-5-phenyl-2-oxazolinyl>-5-methoxynaphthalene 
• 91307-40-3 methyl 5-hydroxy-1-naphthoate 
• 2437-16-3 5-hydroxy-1-naphthoic acid 

Relevant articles and documents

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors

A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulted in a series of benzoic acid analogues that are potent inhibitors of HIV-1 replication against a panel of HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Furthermore, the combination of good antiviral potency, a broad spectrum of activity, and an excellent pharmacokinetic profile provides strong justification for the further development of compound 7 as a potential treatment for wild type and NNRT1-resistant HIV-1 infection.

Oxime ether derivative and preparation method and application thereof

The invention discloses oxime ether derivative and a preparation method and application thereof. The oxime ether derivative is shown as any one of 1) to 6), wherein the 1) is 5-bromine-1-naphthalene formaldehyde oxime ether, the 2) is 5-methoxy-1-naphthalene formaldehyde oxime ether, the 3) is 5-phenyl-1-naphthalene formaldehyde oxime ether, the 4) is 5-p-methoxyphenyl-1-naphthalene formaldehyde oxime ether, the 5) is 5-p-ethoxyphenyl-1-naphthalene formaldehyde oxime ether, and the 6) is 3-5-ethyl(E)-1-naphthalene formaldehyde oxime ether. According to the oxime ether derivative, 1-naphthoic acid is utilized as a raw material; the oxime ether derivative is synthesized by coupling reaction of Suzuki reaction, Heck reaction and the like, acylation reaction and oximation reaction. The compound disclosed by the invention has good antineoplastic activity and has a very good prospect in medicinal development.

Photogeneration of 1,5-naphthoquinone methides via excited-state (formal) intramolecular proton transfer (ESIPT) and photodehydration of 1-naphthol derivatives in aqueous solution

The photochemistry of naphthols 1, 2, 4, 5 and 9, and phenol 10 has been studied in aqueous solution with the primary aim of exploring the viability of such compounds for naphthoquinone and quinone methide photogeneration, along the lines already demonstr