51974-19-7

Basic information

• Product Name: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE
• Synonyms: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE
• CAS NO: 51974-19-7
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 51974-19-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 65–67°C
• Appearance: /
• CAS DataBase Reference: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE(51974-19-7)
• EPA Substance Registry System: (2-HYDROXYPHENYL)(O-TOLYL)METHANONE(51974-19-7)

Safety Data

• Hazardous Substances Data: 51974-19-7(Hazardous Substances Data)

Usage

Preparation

Preparation by hydrogenation of 5-chloro-2-hydroxy- 2?-methylbenzophenone in ethanolic solution in the presence of 10% Pd/C and potassium acetate at r.t. under atmosphere pressure (98%).

Upstream product

• 36804-45-2 (2-aminophenyl)(2-methylphenyl)methanone 
• 52980-94-6 5-chloro-2-hydroxy-2'-methylbenzophenone 
• 7647-01-0 hydrogenchloride 
• 500285-59-6 2-methyl-benzoic acid-(4-chloro-phenyl ester) 
• 106-48-9 4-chloro-phenol 
• 933-88-0 ortho-toluoyl chloride 
• 581060-14-2 C₁₄H₁₄O₂ 
• 119-36-8 methyl salicylate 
• 932-31-0 ortho-tolylmagnesium bromide 
• 118-55-8 phenyl Salicylate 
• 108-88-3 toluene 
• 95-46-5 2-methylphenyl bromide 
• 90-02-8 salicylaldehyde 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 170799-19-6 2-Oxo-4-o-tolyl-2H-chromene-3-carboxylic acid ethyl ester 
• 1026971-44-7 3-Isocyanato-4-o-tolyl-chromen-2-one 
• 170799-21-0 2-Oxo-4-o-tolyl-2H-chromene-3-carboxylic acid 
• 1418635-79-6 (4R)-4-(2-tolyl)-3,4-dihydro-1,2,3-benzoxathiazine-2,2-dioxide 

Relevant articles and documents

Aerobic Copper-Catalyzed Salicylaldehydic Cformyl?H Arylations with Arylboronic Acids

We report a challenging copper-catalyzed Cformyl?H arylation of salicylaldehydes with arylboronic acids that involves unique salicylaldehydic copper species that differ from reported salicylaldehydic rhodacycles and palladacycles. This protocol has high chemoselectivity for the Cformyl?H bond compared to the phenolic O?H bond involving copper catalysis under high reaction temperatures. This approach is compatible with a wide range of salicylaldehyde and arylboronic acid substrates, including estrone and carbazole derivatives, which leads to the corresponding arylation products. Mechanistic studies show that the 2-hydroxy group of the salicylaldehyde substrate triggers the formation of salicylaldehydic copper complexes through a CuI/CuII/CuIII catalytic cycle.

Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2

A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.

Efficient catalytic synthesis method of 2-hydroxybenzophenone compound

The invention discloses a 2-hydroxybenzophenone compound and a green catalytic synthesis method thereof. According to the method, under the conditions of using coumaranone and coumaranone derivativesas raw materials, using nickel chloride as a catalyst, using methylbenzene as a solvent, using di-tert-butyl peroxide as an oxidizing agent, and using sodium carbonate as alkali, the 2-hydroxybenzophenone compound is obtained at high yield. The method has the advantages that the cost is low; the yield is high; the operation is simple and convenient; no pollution is caused and the like. The potential industrial application prospects are realized. The method provides a cheap and green path for the preparation of the 2-hydroxybenzophenone compound.