5198-76-5

Basic information

• Product Name: 2-Chloro-4-(chloromethyl)thiazole
• Synonyms: 2-Chloro-4-(chloromethyl)thiazole;2-CHLORO-4-(CHLOROMETHYL)-1,3-THIAZOLE
• CAS NO: 5198-76-5
• Molecular Formula: C₄H₃Cl₂NS
• Molecular Weight: 168.04432
• EINECS: 604-604-1
• Mol File: 5198-76-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 82℃ (10 Torr)
• Flash Point: 116.3±25.1℃
• Appearance: /
• Density: 1.503±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.584
• PKA: -1.22±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-4-(chloromethyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(chloromethyl)thiazole(5198-76-5)
• EPA Substance Registry System: 2-Chloro-4-(chloromethyl)thiazole(5198-76-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 5198-76-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(chloromethyl)thiazole is a chemical compound with the molecular formula C5H4Cl2NS. It is an organochlorine compound that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Chloro-4-(chloromethyl)thiazole is a thiazole derivative and its structure consists of a thiazole ring with two chlorine atoms and a chloromethyl functional group attached to it. It is classified as a hazardous chemical and can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Additionally, it is considered harmful if ingested and may cause adverse effects on aquatic life if released into the environment.

InChI:InChI=1/C4H3Cl2NS/c5-1-3-2-8-4(6)7-3/h2H,1H2

Upstream product

• 59608-97-8 4-(chloromethyl)thiazol-2-amine hydrochloride 
• 5198-85-6 (2-chlorothiazol-4-yl)methanol 

Downstream Products

• 1033619-90-7 2-chloro-thiazol-4-ylmethyl-4-fluorophenylcarbamic acid tert-butyl ester 
• 1229247-08-8 1-(2-chloro-thiazol-4-ylmethyl)-3-[3-(4-fluoro-phenoxy)-propyl]-1,3-dihydro-benzoimidazol-2-ylideneamine 

Relevant articles and documents

ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R1', R2, R3, R4 R4', and p are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. "