52-26-6 Usage
Description
MORPHINIUM CHLORIDE, also known as the hydrochloride salt of morphine, is a potent opioid receptor agonist derived from the naturally occurring alkaloid, morphine. It is characterized by its white or almost white crystalline powder or colourless, silky needles or cubical masses, which are efflorescent in a dry atmosphere. MORPHINIUM CHLORIDE is widely recognized for its analgesic properties, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
MORPHINIUM CHLORIDE is used as an analgesic for its potent pain-relieving effects. It is particularly effective in managing moderate to severe pain, such as postoperative pain, chronic pain, and pain associated with various medical conditions.
Used in Opioid Receptor Agonist Applications:
In the field of neuroscience and pharmacology, MORPHINIUM CHLORIDE is used as an opioid receptor agonist. It interacts with the opioid receptors in the central nervous system, leading to a range of physiological effects, including pain relief, sedation, and respiratory depression. This application is crucial in understanding the mechanisms of pain and developing new therapeutic strategies for pain management.
Contact allergens
Morphine bitartrate caused contact dermatitis in a
worker at a plant producing opium alkaloids. Morphine
hydrochloride and morphine bitartrate showed patchtest-
positive reactions in another patient with contact
dermatitis working in the production of concentrated
poppy straw. We observed a concomitant reaction
between a morphine base and a codeine base in a
patient with drug skin eruption due to codeine.
Safety Profile
Poison by ingestion,
intraperitoneal, intravenous, parenteral, and
subcutaneous routes. An experimental
teratogen. Experimental reproductive
effects. Abuse leads to habituation or
addiction. When heated to decomposition it
emits very toxic fumes of NOx and HCl.
Check Digit Verification of cas no
The CAS Registry Mumber 52-26-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52-26:
(4*5)+(3*2)+(2*2)+(1*6)=36
36 % 10 = 6
So 52-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1
52-26-6Relevant articles and documents
Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids
Kok, Gaik B.,Pye, Cory C.,Singer, Robert D.,Scammells, Peter J.
experimental part, p. 4806 - 4811 (2010/10/19)
(Figure Presented) A mild and simple two-step Fe(0)-mediated N-demethylation of a number of tertiary N-methyl alkaloids is described. The tertiary N-methylamine is first oxidized to the corresponding N-oxide, which is isolated as the hydrochloride salt. Subsequent treatment of the N-oxide hydrochloride with iron powder readily provides the N-demethylated amine. Representative substrates include a number of opiate and tropane alkaloids. Key intermediates in the synthesis of semisynthetic 14-hydroxy pharmaceutical opiates such as oxycodone and oxymorphone are also readily N-demethylated using this method.