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52-31-3

52-31-3

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52-31-3 Usage

Description

Cyclobarbital, a barbiturate derivative, is a central nervous system depressant with sedative and hypnotic properties. It is commonly used in the medical field for its ability to induce sleep, relieve anxiety, and produce anesthesia. Cyclobarbital works by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain, which results in the suppression of neuronal excitability.

Uses

Used in Pharmaceutical Industry:
Cyclobarbital is used as an anesthetic and sedative for various medical applications, including the treatment of insomnia, anxiety, and seizures. It is particularly effective in inducing sleep and providing preoperative sedation before surgery.
As a Controlled Substance (Depressant):
Cyclobarbital is classified as a controlled substance due to its potential for abuse and dependence. It is a Schedule IV drug, which means it has a lower potential for abuse compared to other controlled substances but still carries a risk of addiction. Medical professionals must carefully monitor patients using Cyclobarbital to prevent misuse and ensure its safe and effective use.
Brand Name:
Phanodorn (Sterling Winthrop) is a brand name under which Cyclobarbital has been marketed. It is available in various forms, such as tablets, capsules, and injectable solutions, to cater to the different needs of patients and healthcare providers.

Originator

Cyclobarbital,Bayer

Manufacturing Process

772.0 g of δ-1,2-cyclohexenylcyanacetic acid ethyl ester are introduced into astirred and ice cooled solution of 92.0 g of sodium in 1500 ml of absolutealcohol. The sodium δ-1,2-cyclohexenylcyanacetic acid ester formed is thengradually treated without ice cooling with 750.0 g of ethyl iodide. The reactionmixture become warm, sodium iodide separates out and the whole is neutralafter a short time. The sodium iodide is filtered off, the filtrate freed fromalcohol by distillation, the residues taken up in water, siphoned off, dried overcalcium chloride and distilled in vacuum, yields δ-1,2-cyclohexenylethylcyanacetic acid ethyl ester, boil point 125°C. 72.0 g ofsodium are dissolved in 1086.0 g of absolute alcohol and boiled for 3.75 hwith 285.0 g of guanidine sulfate, then 221.0 g of δ-1,2-cyclohexenylethylcyanacetic acid ester are added and boiling is continued for afurther 12 h. The residue remaining after distilling off the alcohol is boiledwith 10 times its weight of dilute sulfuric acid and then δ-1,2-cyclohexenylethylbarbituric acid which separates out is recrystallized from hotwater, melting point 170°C

Therapeutic Function

Hypnotic

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: pulmonary consolidation. Used as a central nervous system depressant, hypnotic, and sedative. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.

Check Digit Verification of cas no

The CAS Registry Mumber 52-31-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 52-31:
(4*5)+(3*2)+(2*3)+(1*1)=33
33 % 10 = 3
So 52-31-3 is a valid CAS Registry Number.
InChI:InChI=1S/C12H16N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h6H,2-5,7H2,1H3,(H2,13,14,15,16,17)

52-31-3Relevant articles and documents

Electron paramagnetic resonance study of thermal decomposition of molecules. I. Barbituric acid derivatives.

Herak,Herak

, p. 7646 - 7649 (1972)

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