52-77-7 Usage
Description
(17beta)-17-ethynylestra-1(10),2,4-trien-17-ol, also known as Ethynylestradiol, is a synthetic estrogen medication with potent estrogenic activity. It is commonly used in hormonal contraceptive pills, hormone replacement therapy, and for treating menopausal symptoms. Ethynylestradiol works by suppressing ovulation, thickening cervical mucus to prevent sperm from reaching the egg, and thinning the uterine lining to prevent implantation of a fertilized egg. As a potent estrogen, it has both beneficial and potentially harmful effects, such as an increased risk of blood clots, stroke, and breast cancer. It is crucial to use this medication carefully and as directed by a medical professional to minimize potential risks.
Uses
Used in Pharmaceutical Industry:
(17beta)-17-ethynylestra-1(10),2,4-trien-17-ol is used as a synthetic estrogen medication for various applications in the pharmaceutical industry. It is primarily used in the formulation of hormonal contraceptive pills to prevent pregnancy by suppressing ovulation and altering the reproductive system. Additionally, it is used in hormone replacement therapy to alleviate symptoms of menopause and treat conditions related to estrogen deficiency.
Used in Hormonal Contraceptive Pills:
(17beta)-17-ethynylestra-1(10),2,4-trien-17-ol is used as an active ingredient in hormonal contraceptive pills for the purpose of preventing pregnancy. It achieves this by suppressing ovulation, thickening cervical mucus to prevent sperm from reaching the egg, and thinning the uterine lining to prevent implantation of a fertilized egg.
Used in Hormone Replacement Therapy:
(17beta)-17-ethynylestra-1(10),2,4-trien-17-ol is used as a component in hormone replacement therapy to treat menopausal symptoms and conditions related to estrogen deficiency. It helps alleviate symptoms such as hot flashes, night sweats, and vaginal dryness, as well as reducing the risk of osteoporosis and cardiovascular diseases in postmenopausal women.
Check Digit Verification of cas no
The CAS Registry Mumber 52-77-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52-77:
(4*5)+(3*2)+(2*7)+(1*7)=47
47 % 10 = 7
So 52-77-7 is a valid CAS Registry Number.
52-77-7Relevant articles and documents
Analogues of [(triethylsilyl)ethynyl]estradiol as potential antifertility agents
Peters,Crowe,Avery,Chong,Tanabe
, p. 572 - 576 (2007/10/02)
Various 17α-ethynylsteroids were prepared and derivatized as the corresponding triethylsilyl compounds 2-35, which were examined for a ratio of antifertility to estrogenic activity that would be more beneficial than that of the presently used agent. Among the triethylsilyl compounds evaluated, only 23 displayed this desired ratio, although two other compounds without the triethylsilyl moiety, 18 and 26, shared similar characteristics. In a previous study of ethynyl estradiol derivatives by the authors, it was found that even a small presence of silicon was beneficial. The silyl derivatives showed a reduction in estrogenic activity along with a retention of the level of oral antifertility activity. In relation to endocrine disorders and the undesired side effects of prescribed contraceptives, the finding is positive. In the present study, the effects of structural changes in the A, B, C, and D rings of the ethynyl estradiol steroidal nucleus were examined in conjunction with C-21 triethylsilyl moiety. The general method of Ethynylation and Triethylsilylation are described in detail and the oral antifertility and oral estrogenic potencies of the compounds are described and compared. Of the various triethylsilyl compounds examined for an antifertility to estrogenic activity ration that would be more beneficial than that of a present agent, only 23 manifested the desired ratio. Compound 18, which was 66% as effective as ethynyl estradiol as an antifertility agent, had 0.1% of the estrogenic activity of ethynyl estradiol and was singled out for the greatest separation between antifertility activity and estrogenic activity. 2 groups of rats, 1 immature females and the other adult, female, cycling rats were tested for oral estrogenic activity and oral antifertility activity, respectively.
