52047-13-9

Basic information

• Product Name: Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate
• Synonyms: Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate
• CAS NO: 52047-13-9
• Molecular Formula: C₆H₃Cl₂N₃O₄
• Molecular Weight: 252.01172
• Mol File: 52047-13-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 383.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.685±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -9.02±0.39(Predicted)
• CAS DataBase Reference: Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate(52047-13-9)
• EPA Substance Registry System: Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate(52047-13-9)

Safety Data

• Hazardous Substances Data: 52047-13-9(Hazardous Substances Data)

Usage

General Description

Methyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate is a chemical compound with the molecular formula C7H4Cl2N2O4. It is a pale yellow solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Methyl 2,6-dichloro-5-nitropyriMidine-4-carboxylate is known for its use as a building block in the preparation of pyrimidine derivatives, which have been studied for their potential therapeutic applications in areas such as anticancer, antiviral, and antibacterial treatments. Methyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate also exhibits strong electron-withdrawing properties due to its nitro and ester functional groups, making it a valuable reagent in organic synthesis. Additionally, it is important to handle this compound with care due to its potential hazards and toxic effects when ingested or inhaled.

Upstream product

• 65-86-1 2,4-dihydroxypyrimidine-6-carboxylic acid 
• 17687-24-0 2,6-dihydroxy-5-nitropyrimidine-4-carboxylic acid 
• 6311-73-5 methyl 2,6-dihydroxy-5-nitropyrimidine-4-carboxylate 
• 6311-73-5 methyl 5-nitroorotate 

Downstream Products

• 502184-51-2 methyl 5-amino-2,6-dichloropyrimidine-4-carboxylate 
• 1022158-71-9 6-(1-benzenesulfonyl-1H-indol-4-ylamino)-2-chloro-5-nitro-pyrimidine-4-carboxylic acid methyl ester 
• 1022157-34-1 methyl 2-chloro-5-nitro-6-(phenylamino)pyrimidine-4-carboxylate 
• 849703-65-7 6-(4-methoxy-benzylamino)-5-nitro-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester 
• 766557-54-4 2-chloro-6-(4-methoxy-benzylamino)-5-nitro-pyrimidine-4-carboxylic acid methyl ester 

Relevant articles and documents

Pyrimidine fused ring derivatives and application thereof in medicine

The invention relates to compounds shown in a general formula (I) or stereoisomers, deuterated compounds, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or co-crystal of the compounds, an intermediate and a preparation method of the compounds, and application of the compounds in preparation of drugs for treating diseases related to activity or expression quantity of KRas-G12C.

CARBAZOLE AND CARBOLINE KINASE INHIBITORS

The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

Effect of a-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines

Several A-ring-modified analogues of the DNA-binding antitumor agent DC- 81 (5) have been synthesized in order to study structure- reactivity/cytotoxicity relationships. For two molecules (23 and 30) the modifications required the addition of a fourth rin