52055-86-4

Basic information

• Product Name: 1-(4-METHOXYBENZOFURAN-5-YL)ETHANONE
• Synonyms: 1-(4-METHOXYBENZOFURAN-5-YL)ETHANONE
• CAS NO: 52055-86-4
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Mol File: 52055-86-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-METHOXYBENZOFURAN-5-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYBENZOFURAN-5-YL)ETHANONE(52055-86-4)
• EPA Substance Registry System: 1-(4-METHOXYBENZOFURAN-5-YL)ETHANONE(52055-86-4)

Safety Data

• Hazardous Substances Data: 52055-86-4(Hazardous Substances Data)

Upstream product

• 873378-14-4 4-methoxy-benzofuran-5-carbonyl chloride 
• 18815-73-1 methylzinc iodide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 69722-46-9 1-(4-hydroxy-benzofuran-5-yl)-ethanone 
• 74-88-4 methyl iodide 
• 492440-03-6 1-[4-(2,2-diethoxyethoxy)-2-hydroxyphenyl]ethan-1-one 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 484-33-3 pongamol 

Downstream Products

• 484-33-3 pongamol 
• 130824-74-7 (E)-9-O-Methylpongamol 
• 64280-20-2 ovalitenin A 
• 83728-90-9 2'-Methoxy-4-methylfurano<3'',2'':3',4'>chalcone 
• 121324-08-1 (2Z)-3-hydroxy-1-(4–methoxy-1-benzofuran-5-yl)-3-phenylprop 2-en-1-one 
• 69722-46-9 1-(4-hydroxy-benzofuran-5-yl)-ethanone 
• 101450-96-8 1-(4-methoxy-benzofuran-5-yl)-ethanone-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

Preparation method and application of pongamol

The invention belongs to the field of medicinal chemistry, and relates to a preparation method and application of pongamol. The preparation method comprises the following steps: with 1,3-cyclohexanedione (6) as a starting raw material, carrying out a cyclization reaction to obtain 6,7-dihydro-4-(5H)-benzofuranone (7); carrying out acylation reaction on the compound (7) to obtain 5-acetyl-6,7-dihydro-4-(5H)-benzofuranone (8); carrying out dehydrogenation reaction on the compound (8) to obtain 1-(4-hydroxy-5-benzofuryl) ethyl ketone (3); carrying out methylation reaction on the compound (3) to obtain 1-(4-methoxy-5-benzofuryl) ethyl ketone (4); and condensing the compound (4) with benzoyl chloride to obtain the pongamol. According to the preparation method, the selected reagents are cheap and easy to obtain, the post-treatment method is simple, the reaction conditions are mild, and the product yield is high. Pharmacological activity experiments show that the synthesized compound has nerve injury resistance and anti-inflammatory activity, which means that the compound has a good application prospect in the field of treatment of nerve injury and inflammation related diseases.

Amberlyst 15-catalyzed efficient synthesis of 5-acetyl-4-hydroxy-coumarone and 5-acetyl-6-hydroxy-coumarone: Crucial precursors for several naturally occurring furanoflavones

A novel approach to the total synthesis of naturally occurring furanoflavones and furanochalcones is described. Angular and linear furanoflavones and furanochalcones have been prepared in just four steps, using economical reagents and simple reaction cond