52083-08-6

Basic information

• Product Name: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride
• Synonyms: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride;4-hydroxy-naphthalene-1,8-dicarboxylic anhydride;6-hydroxybenzo[de]isochromene-1,3-dione;4-hydroxy-1,8-naphthalic anhydride
• CAS NO: 52083-08-6
• Molecular Formula: C₁₂H₆O₄
• Molecular Weight: 214.17364
• Mol File: 52083-08-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 350-351 °C
• Boiling Point: 507.6±33.0 °C(Predicted)
• Appearance: /
• Density: 1.585±0.06 g/cm3(Predicted)
• PKA: 7.27±0.20(Predicted)
• CAS DataBase Reference: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(52083-08-6)
• EPA Substance Registry System: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(52083-08-6)

Safety Data

• Hazardous Substances Data: 52083-08-6(Hazardous Substances Data)

Usage

Description

4-Hydroxy-1,8-naphthalenedicarboxylic anhydride, also known as 1,8-naphthalic anhydride, is a chemical compound with the molecular formula C12H6O6. It is a white solid at room temperature and is insoluble in water. This versatile building block is commonly used as a precursor in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
4-Hydroxy-1,8-naphthalenedicarboxylic anhydride is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. Its unique chemical structure allows for the development of new therapeutic agents with potential applications in treating various diseases and conditions.
Used in Dye and Pigment Industry:
4-Hydroxy-1,8-naphthalenedicarboxylic anhydride is used as a precursor in the production of dyes and pigments. Its chemical properties make it suitable for the creation of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Chemical Industry:
4-Hydroxy-1,8-naphthalenedicarboxylic anhydride is used as a key starting material for the synthesis of a wide range of organic compounds. Its versatility allows for the development of new chemical products and processes, contributing to the advancement of the chemical industry.

Upstream product

• 6492-86-0 4-amino-1,8-naphthalic anhydride 
• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 
• 26848-63-5 4-sulfo-naphthalene-1,8-dicarboxylic acid 

Downstream Products

• 18644-22-9 4-amino-naphthalene-1,8-dicarboxylic acid 
• 90-15-3 α-naphthol 
• 2437-16-3 5-hydroxy-1-naphthoic acid 
• 4053-08-1 p-chloro-1,8-naphthalicanhydride 

Relevant articles and documents

Endoplasmic reticulum-targetable fluorescent probe for visualizing HClO in EC1 cells

The endoplasmic reticulum is the largest organelle in the cell. Studies have shown that the concentration of HClO is related to many diseases. A new type of probe R1 has positioned to the endoplasmic reticulum. The probe shows good positioning effect, excellent selectivity and high sensitivity, excellent anti-interference, and can quickly reach the response platform. The obvious color change can be used for naked eye observation. Due to its low cytotoxicity, probe R1 was successfully used for EC1 cells imaging under a laser scanning confocal microscope.

A Naphthalimide-Based Cd2+Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions

We have developed a novel naphthalimide-based Cd2+fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity toward Cd2+through its high association constant [K=(2.10±0.423)×106], and a practical working pH range. Membrane-permeability was conferred on 1 by replacing the imide and amide substituents with n-butyl groups, and hence the derivative (4) has found practical utility on fluorescent imaging of Cd2+in HeLa cells. Comparison of fluorescent properties between various compounds derived from 1 has demonstrated that the carbamoylmethyl groups in 1 function not only as Cd2+chelators but also as promoters for photoinduced electron transfer (PET) by lowering the basicity of the two tertiary amino groups. As a result, 1 and 4 exhibited highly practical performance as Cd2+probes under neutral conditions.